INPP4B Antikörper (N-Term)

Produktnummer ABIN6992164

Produktdetails anti-INPP4B Antikörper

Target: INPP4B (Inositol Polyphosphate-4-Phosphatase, Type II, 105kDa (INPP4B))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser INPP4B Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunocytochemistry (ICC)

Spezifität: INPP4B antibody is human, mouse and rat reactive. At least two isoforms of INPP4B are known to exist, this antibody only detects the longer isoform. INPP4B antibody is predicted to not cross-react with INPP4A.

Aufreinigung: INPP4B antibody is affinity chromatography purified via peptide column.

Immunogen: INPP4B antibody was raised against a 17 amino acid peptide near the amino terminus of human INPP4B. The immunogen is located within the last 50 amino acids of INPP4B.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: INPP4B antibody can be used for detection of INPP4B by Western blot at 1 - 2 μ,g/mL. Antibody can also be used for immunocytochemistry starting at 2.5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunocytochemistry in mouse samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: INPP4B antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: INPP4B antibody can be stored at 4°C for three months and -20°C, stable for up to one year.

Details zu INPP4B

Target: INPP4B (Inositol Polyphosphate-4-Phosphatase, Type II, 105kDa (INPP4B))

Andere Bezeichnung: INPP4B (INPP4B Produkte)

Synonyme: E130107I17Rik antikoerper, inositol polyphosphate-4-phosphatase, type II antikoerper, inositol polyphosphate-4-phosphatase type II B antikoerper, Inpp4b antikoerper, INPP4B antikoerper

Hintergrund: Inositol polyphosphate 4-phosphatase type II (INPP4B) is one of the enzymes involved in phosphatidylinositol signaling pathways. It removes the phosphate group at position 4 of the inositol ring from inositol 3,4-bisphosphate (1). INPP4B can function as a tumor suppressor by inhibiting PI3K signaling. In human epithelial cells, knockdown of INPP4B expression resulted in enhanced Akt activation, anchorage-independent growth, and enhanced overall motility (2). It is thought INPP4B may also have oncogenic functions as INPP4B-dependent PI3K signaling is mediated by SGK3 in breast cancer cells and expression of INPP4B leads to enhanced SGK3 activation and suppression of AKT phosphorylation (3).

Molekulargewicht: Predicted: 102 kDa

Observed: 100 kDa

Gen-ID: 8821

NCBI Accession: NP_003857

UniProt: Q9BS68