At least three isoforms of RC3H1 are known to exist, this antibody will detect all three isoforms.
Aufreinigung
RC3H1 Antibody is affinity chromatography purified via peptide column.
Immunogen
Rabbit polyclonal RC3H1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human RC3H1. The immunogen is located within amino acids 1040 - 1090 of RC3H1.
RC3H1
Reaktivität: Human
WB, ELISA, IHC
Wirt: Kaninchen
Polyclonal
HRP
Applikationshinweise
RC3H1 antibody can be used for detection of RC3H1 by Western blot at 1 - 2 μ,g/mL.
Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
Beschränkungen
Nur für Forschungszwecke einsetzbar
Format
Liquid
Konzentration
1 mg/mL
Buffer
RC3H1 Antibody is supplied in PBS containing 0.02 % sodium azide.
Konservierungsmittel
Sodium azide
Vorsichtsmaßnahmen
This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C,4 °C
Informationen zur Lagerung
RC3H1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
Target
RC3H1
(Ring Finger and CCCH-Type Domains 1 (RC3H1))
RNF198 antikoerper, ROQUIN antikoerper, RC3H1 antikoerper, si:dkey-192m14.4 antikoerper, 5730557L09Rik antikoerper, Gm551 antikoerper, N28103 antikoerper, mKIAA2025 antikoerper, RGD1563512 antikoerper, rc3h1 antikoerper, ring finger and CCCH-type domains 1 antikoerper, ring finger and CCCH-type domains 1a antikoerper, ring finger and CCCH-type zinc finger domains 1 antikoerper, RING CCCH (C3H) domains 1 antikoerper, ring finger and CCCH-type domains 1 L homeolog antikoerper, RC3H1 antikoerper, rc3h1a antikoerper, Rc3h1 antikoerper, rc3h1.L antikoerper
Hintergrund
RC3H1 Antibody: The ring finger protein RC3H1, also known as Roquin, is a highly conserved member of the RING type ubiquitin ligase protein family whose M199R mutation leads to the excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, a strain with excessive IL-21 production and high titers of autoantibodies. The complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity in RC3H1-null mice, suggesting that the mutant RC3H1 is more disruptive to the immune system than its complete loss.