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RC3H1 Antikörper (C-Term)

RC3H1 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC (p), IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6991828
  • Target Alle RC3H1 Antikörper anzeigen
    RC3H1 (Ring Finger and CCCH-Type Domains 1 (RC3H1))
    Bindungsspezifität
    • 9
    • 7
    • 5
    • 2
    • 1
    • 1
    • 1
    AA 1040-1090, C-Term
    Reaktivität
    • 20
    • 4
    • 2
    • 2
    • 1
    Human, Maus, Ratte
    Wirt
    • 20
    Kaninchen
    Klonalität
    • 19
    • 1
    Polyklonal
    Konjugat
    • 10
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser RC3H1 Antikörper ist unkonjugiert
    Applikation
    • 20
    • 13
    • 13
    • 4
    • 1
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (IF)
    Spezifität
    At least three isoforms of RC3H1 are known to exist, this antibody will detect all three isoforms.
    Aufreinigung
    RC3H1 Antibody is affinity chromatography purified via peptide column.
    Immunogen
    Rabbit polyclonal RC3H1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human RC3H1. The immunogen is located within amino acids 1040 - 1090 of RC3H1.
    Isotyp
    IgG
    Top Product
    Discover our top product RC3H1 Primärantikörper
  • Applikationshinweise
    RC3H1 antibody can be used for detection of RC3H1 by Western blot at 1 - 2 μ,g/mL.

    Antibody validated: Western Blot in human samples, Immunohistochemistry in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    RC3H1 Antibody is supplied in PBS containing 0.02 % sodium azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,4 °C
    Informationen zur Lagerung
    RC3H1 antibody can be stored at 4°C for three months and -20°C, stable for up to one year.
  • Target
    RC3H1 (Ring Finger and CCCH-Type Domains 1 (RC3H1))
    Andere Bezeichnung
    RC3H1 (RC3H1 Produkte)
    Synonyme
    RNF198 antikoerper, ROQUIN antikoerper, RC3H1 antikoerper, si:dkey-192m14.4 antikoerper, 5730557L09Rik antikoerper, Gm551 antikoerper, N28103 antikoerper, mKIAA2025 antikoerper, RGD1563512 antikoerper, rc3h1 antikoerper, ring finger and CCCH-type domains 1 antikoerper, ring finger and CCCH-type domains 1a antikoerper, ring finger and CCCH-type zinc finger domains 1 antikoerper, RING CCCH (C3H) domains 1 antikoerper, ring finger and CCCH-type domains 1 L homeolog antikoerper, RC3H1 antikoerper, rc3h1a antikoerper, Rc3h1 antikoerper, rc3h1.L antikoerper
    Hintergrund
    RC3H1 Antibody: The ring finger protein RC3H1, also known as Roquin, is a highly conserved member of the RING type ubiquitin ligase protein family whose M199R mutation leads to the excessive production of follicular helper T cells and germinal centers in the sanroque strain of mice, a strain with excessive IL-21 production and high titers of autoantibodies. The complete loss of RC3H1 induces early death and immune deregulation but not autoimmunity in RC3H1-null mice, suggesting that the mutant RC3H1 is more disruptive to the immune system than its complete loss.
    Molekulargewicht
    125 kDa
    Gen-ID
    149041
    NCBI Accession
    NP_742068
    UniProt
    Q5TC82
    Pathways
    Ribonucleoprotein Complex Subunit Organization, Activated T Cell Proliferation
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