ZGPAT Antikörper (C-Term)

Produktnummer ABIN6991617

Produktdetails anti-ZGPAT Antikörper

Target: ZGPAT (Zinc Finger, CCCH-Type with G Patch Domain (ZGPAT))

Bindungsspezifität: C-Term

Reaktivität: Human

Wirt: Huhn

Klonalität: Polyklonal

Konjugat: Dieser ZGPAT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Spezifität: Multiple isoforms of ZGPAT are known to exist.

Aufreinigung: ZGPAT Antibody is affinity chromatography purified via peptide column.

Immunogen: ZGPAT antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ZGPAT. The immunogen is located within the last 50 amino acids of ZGPAT.

Isotyp: IgY

Anwendungsinformationen

Applikationshinweise: ZGPAT antibody can be used for detection of ZGPAT by Western blot at 1 μ,g/mL. Antibody can also be used for immunofluorescence starting at 20 μ,g/mL. For immunofluorescence start at 20 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunofluorescence in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: ZGPAT Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: ZGPAT antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu ZGPAT

Target: ZGPAT (Zinc Finger, CCCH-Type with G Patch Domain (ZGPAT))

Andere Bezeichnung: ZGPAT (ZGPAT Produkte)

Synonyme: zc3h9 antikoerper, gpatc6 antikoerper, gpatch6 antikoerper, zc3hdc9 antikoerper, GPATC6 antikoerper, GPATCH6 antikoerper, KIAA1847 antikoerper, ZC3H9 antikoerper, ZC3HDC9 antikoerper, ZIP antikoerper, 1500006I01Rik antikoerper, BC021513 antikoerper, RGD1310801 antikoerper, zgc:63730 antikoerper, zinc finger CCCH-type and G-patch domain containing antikoerper, zinc finger, CCCH-type with G-patch domain L homeolog antikoerper, zinc finger, CCCH-type with G-patch domain antikoerper, zinc finger, CCCH-type with G patch domain antikoerper, ZGPAT antikoerper, zgpat.L antikoerper, zgpat antikoerper, Zgpat antikoerper

Hintergrund: ZGPAT Antibody: The Zinc finger CCCH-type with G patch domain-containing protein (ZGPAT), is a transcriptional repressor that regulates several cellular pathways including EGFR pathways that are involved in cell proliferation, migration and survival. ZGPAT recruits the Mi-2/NuRD complex and represses the expression of EGFR. ZGPAT is down-regulated in breast carcinomas and its expression is negatively correlated with that of EGFR, suggesting that it may be a potential target for breast cancer therapy. Multiple isoforms of ZGPAT are known to exist, including sZIP, which binds to the Mi-2/NuRD complex but lacks the DNA binding component of full-length ZGPAT, thereby antagonizing transcription repression and growth inhibition by ZGPAT.

Gen-ID: 84619

NCBI Accession: NP_115916

UniProt: Q8N5A5

Pathways: EGFR Signaling Pathway