SPINK7/ECRG2 Antikörper (C-Term)

Produktnummer ABIN6991593

Produktdetails anti-SPINK7/ECRG2 Antikörper

Target: SPINK7/ECRG2 (SPINK7) (Serine Peptidase Inhibitor, Kazal Type 7 (SPINK7))

Bindungsspezifität: C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Huhn

Klonalität: Polyklonal

Konjugat: Dieser SPINK7/ECRG2 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Spezifität: ECRG2 antibody is predicted to not cross-react with other ECRG family members

Aufreinigung: ECRG2 Antibody is affinity chromatography purified via peptide column.

Immunogen: ECRG2 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human ECRG2. The immunogen is located within the last 50 amino acids of ECRG2.

Isotyp: IgY

Anwendungsinformationen

Applikationshinweise: ECRG2 antibody can be used for detection of ECRG2 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in mouse samples and Immunohistochemistry in rat samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: ECRG2 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: ECRG2 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu SPINK7/ECRG2

Target: SPINK7/ECRG2 (SPINK7) (Serine Peptidase Inhibitor, Kazal Type 7 (SPINK7))

Andere Bezeichnung: ECRG2 (SPINK7 Produkte)

Synonyme: Ecg2 antikoerper, Ecrg2 antikoerper, OM antikoerper, ECG2 antikoerper, ECRG2 antikoerper, EG408198 antikoerper, serine peptidase inhibitor, Kazal type 7 antikoerper, serine peptidase inhibitor, Kazal type 7 (putative) antikoerper, Spink7 antikoerper, SPIK7 antikoerper, SPINK7 antikoerper

Hintergrund: ECRG2 Antibody: The esophageal cancer-susceptibility gene 2 (ECRG2), also known as SPINK7, is a novel tumor suppressor gene identified from the human esophagus. It interacts directly with metallothionein 2A and urokinase-type plasminogen activator (uPA), and downregulates the activity of uPA, leading to reduced cancer cell migration, invasion and metastasis. ECRG2 forms a complex with uPA and its receptor uPAR, modifying the dynamic association of uPAR with beta1 integrins and disrupting the Src/MAP kinase pathway that normally stimulates cell migration and invasion. ECRG2 may thus represent a novel therapeutic target for cancer.

Molekulargewicht: Predicted: 9 kDa

Observed: 14 kDa

Gen-ID: 84651

UniProt: P58062