NSMCE2 Antikörper (C-Term)

Produktnummer ABIN6991340

Produktdetails anti-NSMCE2 Antikörper

Target: NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))

Bindungsspezifität: AA 170-220, C-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NSMCE2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Aufreinigung: MMS21 Antibody is affinity chromatography purified via peptide column.

Immunogen: MMS21 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human MMS21. The immunogen is located within amino acids 170 - 220 of MMS21.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: MMS21 antibody can be used for detection of MMS21 by Western blot at 0.5 - 1 μ,g/mL.

Antibody validated: Western Blot in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: MMS21 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: MMS21 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu NSMCE2

Target: NSMCE2 (E3 SUMO-Protein Ligase NSE2 (NSMCE2))

Andere Bezeichnung: MMS21 (NSMCE2 Produkte)

Synonyme: 1110014D18Rik antikoerper, AI661537 antikoerper, RGD1305156 antikoerper, C8orf36 antikoerper, MMS21 antikoerper, NSE2 antikoerper, ZMIZ7 antikoerper, Non-SMC element 2 antikoerper, NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase antikoerper, NSE2/MMS21 homolog, SMC5-SMC6 complex SUMO ligase L homeolog antikoerper, Smc5-6 complex non-SMC subunit 2 antikoerper, Nsmce2 antikoerper, NSMCE2 antikoerper, nsmce2.L antikoerper, nse2 antikoerper

Hintergrund: MMS21 Antibody: MMS21, also known as NSE2, is a SUMO ligase that in combination with the SMC5/6 complex is required for the prevention of DNA damage induced apoptosis by facilitating DNA repair in human cells. MMS21-dependent sumoylation is integral and important to the cohesion mechanism and mitotic progression, this function appears to be independent of SMC6. MMS21 mediates SUMO attachment to various proteins such as SMC6L1 and TRAX, and possibly the cohesin components RAD21 and STAG2.

Molekulargewicht: Predicted: 27 kDa

Observed: 30 kDa

Gen-ID: 286053

NCBI Accession: NP_775956

UniProt: Q96MF7