CCDC98 Antikörper (N-Term)

Produktnummer ABIN6990791

Produktdetails anti-CCDC98 Antikörper

Target: CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))

Bindungsspezifität: AA 80-130, N-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CCDC98 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: CCDC98 Antibody is affinity chromatography purified via peptide column.

Immunogen: CCDC98 antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human CCDC98. The immunogen is located within amino acids 80 - 130 of CCDC98.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: CCDC98 antibody can be used for detection of CCDC98 by Western blot at 1 μ,g/mL. Antibody can also be used for immunohistochemistry starting at 5 μ,g/mL.

Antibody validated: Western Blot in human samples and Immunohistochemistry in human samples. All other applications and species not yet tested.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: CCDC98 Antibody is supplied in PBS containing 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,4 °C

Informationen zur Lagerung: CCDC98 antibody can be stored at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu CCDC98

Target: CCDC98 (FAM175A) (Family with Sequence Similarity 175, Member A (FAM175A))

Andere Bezeichnung: CCDC98 (FAM175A Produkte)

Synonyme: CCDC98 antikoerper, abra1 antikoerper, ccdc98 antikoerper, fam175a antikoerper, ABRA1 antikoerper, 3830405G04Rik antikoerper, 5630400M01Rik antikoerper, AI506069 antikoerper, AL024423 antikoerper, AV118690 antikoerper, Ccdc98 antikoerper, RGD1305287 antikoerper, zgc:103522 antikoerper, abraxas 1, BRCA1 A complex subunit antikoerper, Coiled-coil domain-containing protein 98 antikoerper, BRCA1 A complex subunit antikoerper, family with sequence similarity 175 member A antikoerper, abraxas 2a, BRISC complex subunit antikoerper, abraxas 1, BRCA1 A complex subunit S homeolog antikoerper, ABRAXAS1 antikoerper, abraxas1 antikoerper, Abraxas1 antikoerper, FAM175A antikoerper, abraxas2a antikoerper, abraxas1.S antikoerper

Hintergrund: CCDC98 Antibody: CCDC98, also known as Abraxas 1, was identified through protein binding studies using the breast and ovarian predisposition protein BRCA1 as the binding target. CCDC98 recruits RAP80, a ubiquitin-binding protein, to BRCA1, allowing the formation of BRCA1 foci in response to DNA damage caused by ionizing radiation. Both CCDC98 and RAP80 are required for DNA damage resistance, G2-M checkpoint control, and DNA repair. Cells depleted of either CCDC98 or RAP80 exhibited increased sensitivity to ionizing radiation, although not as much as in BRCA1-depleted cells, suggesting that CCDC98 and RAP80 control only part of the DNA damage response role of BRCA1. At least two isoforms of CCDC98 are known to exist.

Gen-ID: 84142

NCBI Accession: NP_620775

UniProt: Q6UWZ7

Pathways: DNA Reparatur, Positive Regulation of Response to DNA Damage Stimulus