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Rekombinanter SARS-CoV-2 Spike S1 Antikörper (Biotin)

Reaktivität: SARS Coronavirus-2 (SARS-CoV-2) ELISA Wirt: Human Monoclonal H6 Biotin scFv fragment Recombinant Antibody
Produktnummer ABIN6953155
  • Target Alle SARS-CoV-2 Spike S1 Antikörper anzeigen
    SARS-CoV-2 Spike S1
    Antikörpertyp
    Recombinant Antibody
    Fragment
    scFv fragment
    Reaktivität
    • 44
    • 7
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    SARS Coronavirus-2 (SARS-CoV-2)
    Wirt
    • 18
    • 10
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Klonalität
    • 31
    • 9
    • 5
    Monoklonal
    Konjugat
    • 40
    • 2
    • 1
    • 1
    • 1
    Dieser SARS-CoV-2 Spike S1 Antikörper ist konjugiert mit Biotin
    Applikation
    • 44
    • 9
    • 9
    • 7
    • 5
    • 5
    • 5
    • 4
    • 4
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    ELISA
    Produktmerkmale
    Recombinant anti-SARS-CoV-2 spike Mouse ScFv is expressed from 293 cells (HEK293) with a human IgG1 Fc tag on C-terminal.
    Mouse scFv fusion with human IgG1 Fc
    AA 16-685
    Aufreinigung
    Affinity-chromatography
    Immunogen
    Recombinant Human Novel Coronavirus Spike glycoprotein (S) (16-685aa)
    Klon
    H6
    Isotyp
    IgG1
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  • Applikationshinweise
    Optimal working dilution should be determined by the investigator.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer
    50 % Glycerol, 0.01M PBS, pH 7.4, 0.03 % Proclin 300
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze
  • Target
    SARS-CoV-2 Spike S1
    Abstract
    SARS-CoV-2 Spike S1 Produkte
    Synonyme
    E2 antikoerper, Surface Glycoprotein antikoerper, S antikoerper
    Substanzklasse
    Viral Protein
    Hintergrund
    Spike glycoprotein comprises two functional subunits responsible for binding to the host cell receptor (S1 subunit) and fusion of the viral and cellular membranes (S2 subunit). For many coronavirus (CoVs), S is cleaved at the boundary between the S1 and S2 subunits, which remain non-covalently bound in the prefusion conformation. The distal S1 subunit comprises the receptor-binding domain(s) and contributes to stabilization of the prefusion state of the membrane-anchored S2 subunit that contains the fusion machinery. S is further cleaved by host proteases at the so-called S2' site located immediately upstream of the fusion peptide in all CoVs. This cleavage has been proposed to activate the protein for membrane fusion via extensive irreversible conformational changes. However, different CoVs use distinct domains within the S1 subunit to recognize a variety of attachment and entry receptors, depending on the viral species. Endemic human coronaviruses OC43 and HKU1 attach via their S domain A to 5-N-acetyl-9-O-acetyl-sialosides found on glycoproteins and glycolipids at the host cell surface to enable entry into susceptible cells. MERS-CoV S uses domain A to recognize non-acetylated sialoside attachment receptors, which likely promote subsequent binding of domain B to the entry receptor, dipeptidyl-peptidase 4. SARS-CoV and several SARS-related coronaviruses (SARSr-CoV) interact directly with angiotensin-converting enzyme 2 (ACE2) via SB to enter target cells.
    Gen-ID
    43740568
    UniProt
    P0DTC2
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