SFPQ Antikörper

Produktnummer ABIN6944866

Produktdetails anti-SFPQ Antikörper

Target: SFPQ (Splicing Factor Proline/glutamine-Ric (SFPQ))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser SFPQ Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: Recombinant protein within Human SFPQ aa 600 to the C-terminus

Klon: 2C6

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu SFPQ

Target: SFPQ (Splicing Factor Proline/glutamine-Ric (SFPQ))

Andere Bezeichnung: SFPQ (SFPQ Produkte)

Synonyme: 1110004P21Rik antikoerper, 2810416M14Rik antikoerper, 5730453G22Rik antikoerper, 9030402K04Rik antikoerper, AU021830 antikoerper, D4Ertd314e antikoerper, Gm12940 antikoerper, OTTMUSG00000009329 antikoerper, PSF antikoerper, REP1 antikoerper, hm:zeh0027 antikoerper, wu:fa11h12 antikoerper, wu:fd10f03 antikoerper, zgc:85935 antikoerper, POMP100 antikoerper, splicing factor proline/glutamine rich (polypyrimidine tract binding protein associated) antikoerper, splicing factor proline/glutamine-rich antikoerper, splicing factor proline and glutamine rich antikoerper, Sfpq antikoerper, sfpq antikoerper, SFPQ antikoerper

Hintergrund:

Synonyms: Splicing factor proline- and glutamine-rich, 100 kDa DNA-pairing protein, DNA-binding p52/p100 complex 100 kDa subunit, Polypyrimidine tract-binding protein-associated-splicing factor, hPOMp100, PSF, PTB-associated-splicing factor, SFPQ.

Background: DNA- and RNA binding protein, involved in several nuclear processes. Essential pre-mRNA splicing factor required early in spliceosome formation and for splicing catalytic step II, probably as a heteromer with NONO. Binds to pre-mRNA in spliceosome C complex, and specifically binds to intronic polypyrimidine tracts. Involved in regulation of signal-induced alternative splicing. Interacts with U5 snRNA, probably by binding to a purine-rich sequence located on the 3' side of U5 snRNA stem 1b. May be involved in a pre-mRNA coupled splicing and polyadenylation process as component of a snRNP-free complex with SNRPA/U1A. The SFPQ-NONO heteromer associated with MATR3 may play a role in nuclear retention of defective RNAs. SFPQ may be involved in homologous DNA pairing, in vitro, promotes the invasion of ssDNA between a duplex DNA and produces a D-loop formation.

Gen-ID: 6421

UniProt: P23246