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PP2A alpha/beta Antikörper

PP2A A/B Reaktivität: Human, Maus, Ratte, Zebrafisch (Danio rerio) WB, IF (cc), IHC (p), IHC Wirt: Kaninchen Monoclonal 11F10 unconjugated
Produktnummer ABIN6944644
  • Target Alle PP2A alpha/beta (PP2A A/B) Produkte
    PP2A alpha/beta (PP2A A/B)
    Reaktivität
    • 44
    • 28
    • 26
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte, Zebrafisch (Danio rerio)
    Wirt
    • 40
    • 2
    • 1
    • 1
    Kaninchen
    Klonalität
    • 35
    • 9
    Monoklonal
    Konjugat
    • 8
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser PP2A alpha/beta Antikörper ist unkonjugiert
    Applikation
    • 37
    • 26
    • 26
    • 14
    • 11
    • 6
    • 6
    • 1
    • 1
    Western Blotting (WB), Immunofluorescence (Cultured Cells) (IF (cc)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (IHC)
    Kreuzreaktivität
    Human, Maus, Ratte, Zebrafisch (Danio rerio)
    Aufreinigung
    Purified by Protein A.
    Immunogen
    Human PP2A alpha + beta aa 250-350
    Klon
    11F10
    Isotyp
    IgG
  • Applikationshinweise
    WB 1:300-5000
    IHC-P 1:200-400
    IF(ICC) 1:50-200
    IHC()
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    PP2A alpha/beta (PP2A A/B)
    Andere Bezeichnung
    PP2A alpha + beta (PP2A A/B Produkte)
    Hintergrund

    Synonyms: Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform, Replication protein C, Serine/threonine-protein phosphatase 2A catalytic subunit beta isoform, PP2A-alpha, RP-C, PPP2CA, PP2A-beta, PPP2CB

    Background: The catalytic subunit of protein phosphatase 2A (PP2A) is inactivated by in vitro phosphorylation of Tyr-307 by receptor and nonreceptor protein tyrosine kinases. The catalytic subunit of PP2A is phosphorylated by tyrosine-specific protein kinases and associates with a variety of regulatory subunits. Phosphorylation is enhanced in the presence of the phosphatase inhibitor okadaic acid, consistent with an autodephosphorylation reaction. Phosphorylation is catalyzed by p60v-src, p56lck, epidermal growth factor receptors, and insulin receptors. Transient deactivation of PP2A might enhance transmission of cellular signals through kinase cascades within cells. In eukaryotes, the phosphorylation and dephosphorylation of proteins on serine and threonine residues is an essential means of regulating a broad range of cellular functions, including cell division, homeostasis and apoptosis. A group of proteins that are intimately involved in this process are the protein phosphatases.

    UniProt
    P62714, P67775
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