PPP2R4 Antikörper (pTyr307)

Produktnummer ABIN6944643

Produktdetails anti-PPP2R4 Antikörper

Target: PPP2R4 (Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4))

Bindungsspezifität: pTyr307

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser PPP2R4 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc))

Kreuzreaktivität: Human, Maus, Ratte

Aufreinigung: Purified by Protein A.

Immunogen: Synthetic phospho-peptide around human PP2A Tyr307

Klon: 29A1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400
IF(ICC) 1:50-200
IHC()

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu PPP2R4

Target: PPP2R4 (Protein Phosphatase 2A Activator, Regulatory Subunit 4 (PPP2R4))

Andere Bezeichnung: PP2A (PPP2R4 Produkte)

Synonyme: PP2A antikoerper, PR53 antikoerper, PTPA antikoerper, 2610042B21Rik antikoerper, C77440 antikoerper, N28142 antikoerper, PTPRA antikoerper, Ppp2r4 antikoerper, fc23d07 antikoerper, ppp2r4 antikoerper, wu:fc23d07 antikoerper, zgc:92766 antikoerper, pp2a antikoerper, ppp2r4.L antikoerper, pr53 antikoerper, ptpa antikoerper, protein phosphatase 2 phosphatase activator antikoerper, protein phosphatase 2 protein activator antikoerper, protein phosphatase 2 phosphatase activator L homeolog antikoerper, PTPA antikoerper, Ptpa antikoerper, ptpa antikoerper, ptpa.L antikoerper

Hintergrund:

Synonyms: PP2A A, PP2A alpha, PP2A B, PP2A beta antibody, PP2A-alpha

Background: Protein phosphatase type 2A (PP2A) is an essential protein serine/threonine phosphatase that is conserved in all eukaryotes. PP2A is a key enzyme within various signal transduction pathways as it regulates fundamental cellular activities such as DNA replication, transcription, translation, metabolism, cell cycle progression, cell division, apoptosis and development. The core enzyme consists of catalytic C and regulatory A (or PR65) subunits, with each subunit represented by _ and _ isoforms. Additional regulatory subunits belong to four different families of unrelated proteins. Both the B (or PR55) and B' regulatory protein families contain _, _, _ and _ isoforms, with the B' family also including an _ protein. B'' family proteins include PR72, PR130, PR59 and PR48 isoforms, while striatin (PR110) and SG2NA (PR93) are both members of the B''' regulatory protein family. These B subunits competitively bind to a shared binding site on the core A subunit. This variable array of holoenzyme components, particularly regulatory B subunits, allows PP2A to act in a diverse set of functions. PP2A function is regulated by expression, localization, holoenzyme composition and post-translational modification. Phosphorylation of PP2A at Tyr307 by Src occurs in response to EGF or insulin and results in a substantial reduction of PP2A activity. Reversible methylation on the carboxyl group of Leu309 of PP2A has been observed. Methylation alters the conformation of PP2A, as well as its localization and association with B regulatory subunits.

UniProt: P62714, P67775

Pathways: PI3K-Akt Signalweg, M Phase, Hepatitis C, Toll-Like Receptors Cascades