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PAK1/2/3 Antikörper (pSer139, pSer141, pSer144)

PAK1/2/3 Reaktivität: Human, Ratte, Maus IHC, WB, IHC (p), IF (cc), FACS Wirt: Kaninchen Monoclonal 9A3 unconjugated
Produktnummer ABIN6944410
  • Target Alle PAK1/2/3 Antikörper anzeigen
    PAK1/2/3 (P21-Activated Kinases 1/2/3 (PAK1/2/3))
    Bindungsspezifität
    • 13
    • 12
    • 11
    • 11
    • 7
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pSer139, pSer141, pSer144
    Reaktivität
    • 35
    • 27
    • 26
    • 1
    • 1
    • 1
    Human, Ratte, Maus
    Wirt
    • 36
    Kaninchen
    Klonalität
    • 34
    • 2
    Monoklonal
    Konjugat
    • 29
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PAK1/2/3 Antikörper ist unkonjugiert
    Applikation
    • 21
    • 20
    • 19
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Flow Cytometry (FACS)
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Purified by Protein A.
    Immunogen
    Synthetic phospho-peptide surrounding S139+S141+S144 of PAK
    Klon
    9A3
    Isotyp
    IgG
    Top Product
    Discover our top product PAK1/2/3 Primärantikörper
  • Applikationshinweise
    WB(1:300-1000), FCM(1:20-100), IF(ICC)(1:50-200), IHC()
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 1xTBS ( pH 7.4), 1 % BSA, 40 %Glycerol and 0.05 % Sodium Azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C for 12 months.
    Haltbarkeit
    12 months
  • Target
    PAK1/2/3 (P21-Activated Kinases 1/2/3 (PAK1/2/3))
    Andere Bezeichnung
    PAK1, PAK2, PAK3 (PAK1/2/3 Produkte)
    Synonyme
    X-PAK1 antikoerper, XPak1 antikoerper, pak antikoerper, pak-1 antikoerper, pakalpha antikoerper, p21 protein (Cdc42/Rac)-activated kinase 1 S homeolog antikoerper, p21 (RAC1) activated kinase 1 antikoerper, pak1.S antikoerper, PAK1 antikoerper
    Hintergrund

    Synonyms: Serine/threonine-protein kinase PAK 1, Alpha-PAK, p21-activated kinase 1, p65-PAK, Serine/threonine-protein kinase PAK 2, Gamma-PAK, PAK65, S6/H4 kinase, p21-activated kinase 2, p58, Serine/threonine-protein kinase PAK 3, Beta-PAK, Oligophrenin-3, p21-activated kinase 3, PAK-1, PAK1, PAK-2, PAK2, PAK-3, PAK3

    Background: Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.

    Gen-ID
    5063
    UniProt
    O75914
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