CYP27B1 Antikörper (AA 1-100) (Biotin)

Produktnummer ABIN6942772

Produktdetails anti-CYP27B1 Antikörper (Biotin)

Target: CYP27B1 (Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1))

Bindungsspezifität: AA 1-100

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CYP27B1 Antikörper ist konjugiert mit Biotin

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Kreuzreaktivität: Maus

Homologie: Human,Rat,Dog,Cow,Sheep,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human CYP27B1

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
IHC-P 1:200-400

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C for 12 months.

Haltbarkeit: 12 months

Details zu CYP27B1

Target: CYP27B1 (Cytochrome P450, Family 27, Subfamily B, Polypeptide 1 (CYP27B1))

Andere Bezeichnung: CYP27B1 (CYP27B1 Produkte)

Synonyme: cp2b antikoerper, cyp1 antikoerper, cyp1alpha antikoerper, cyp27b antikoerper, p450c1 antikoerper, pddr antikoerper, vdd1 antikoerper, vddr antikoerper, vddri antikoerper, vdr antikoerper, CP2B antikoerper, CYP1 antikoerper, CYP1alpha antikoerper, CYP27B antikoerper, P450c1 antikoerper, PDDR antikoerper, VDD1 antikoerper, VDDR antikoerper, VDDRI antikoerper, VDR antikoerper, Cyp40 antikoerper, Cp2b antikoerper, Cyp1 antikoerper, Cyp27b antikoerper, Pddr antikoerper, Vdd1 antikoerper, Vddr antikoerper, VddrI antikoerper, Vdr antikoerper, cytochrome P450 family 27 subfamily B member 1 antikoerper, cytochrome P450, family 27, subfamily B, polypeptide 1 antikoerper, cytochrome P450, family 27, subfamily b, polypeptide 1 antikoerper, cyp27b1 antikoerper, CYP27B1 antikoerper, Cyp27b1 antikoerper

Hintergrund:

Synonyms: 1alpha(OH)ase, 25-hydroxyvitamin D(3) 1-alpha-hydroxylase, 25-hydroxyvitamin D-1 alpha hydroxylase, 25-OHD-1 alpha-hydroxylase, Calcidiol 1-monooxygenase, CP27B_HUMAN, CP2B, CYP1, CYP1ALPHA, CYP27B, Cyp27b1, Cytochrome p450 27B1, Cytochrome p450 27B13, Cytochrome P450 family 27 subfamily B polypeptide 1, Cytochrome P450 subfamily XXVIIB (25-hydroxyvitamin D-1-alpha-hydroxylase) polypeptide 1, Cytochrome P450 subfamily XXVIIB polypeptide 1, Cytochrome P450C1 alpha, Cytochrome P450VD1-alpha, mitochondrial, P450C1 alpha, P450c1, P450C1-alpha, P450VD1-alpha, PDDR, VD3 1A hydroxylase, VDD1, VDDR, VDDR I, VDDRI, VDR.

Background: The cytochrome P450 proteins are monooxygenases that catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. P450 enzymes are classified into subfamilies based on their sequence similarities. CYP27B1, a 508-amino acid protein that belongs to the XXVIIB subfamily of the cytochrome P450 family, localizes to the mitochondrion and is expressed in the kidney. The CYP27B1 protein catalyzes the conversion of 25-hydroxyvitamin D3 (25(OH)D) to 1-alpha,25-dihydroxyvitamin D3 (1,25(OH)2D) and functions in calcium metabolism, normal bone growth, and tissue differentiation. Mutations in the gene which encodes for CYP27B1 cause vitamin D-dependent rickets type 1 (VDDR-1), also designated pseudovitamin D deficiency rickets (PDDR), an autosomal recessive disease characterized by early onset of rickets with hypocalcemia and muscle weakness.

Gen-ID: 1594

UniProt: O15528

Pathways: Metabolism of Steroid Hormones and Vitamin D