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SOX10 Antikörper (AA 115-269)

SOX10 Reaktivität: Human, Maus WB, IHC, StM Wirt: Maus Monoclonal SOX10-1074 unconjugated
Produktnummer ABIN6940625
  • Target Alle SOX10 Antikörper anzeigen
    SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))
    Bindungsspezifität
    • 34
    • 16
    • 10
    • 6
    • 4
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 115-269
    Reaktivität
    • 87
    • 54
    • 39
    • 6
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    Human, Maus
    Wirt
    • 68
    • 38
    • 2
    Maus
    Klonalität
    • 55
    • 53
    Monoklonal
    Konjugat
    • 50
    • 9
    • 6
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser SOX10 Antikörper ist unkonjugiert
    Applikation
    • 83
    • 37
    • 30
    • 28
    • 28
    • 18
    • 15
    • 14
    • 12
    • 10
    • 4
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Staining Methods (StM)
    Spezifität
    The specificity of this monoclonal antibody to its intended target was validated by HuProtTM Array, containing more than 19,000, full-length human proteins. Recognizes a protein of ~55 kDa, identified as SOX10. This MAb is highly specific and does not cross-react with other members of the SOX-family. SOX genes comprise a family of genes that are related to the mammalian sex-determining gene SRY. These genes similarly contain sequences that encode for the HMG-box domain, which is responsible for the sequence-specific DNA-binding activity. SOX-10 is a sensitive marker of melanoma, including conventional, spindled, and desmoplastic subtypes. It is expressed by metastatic melanomas and nodal capsular nevus in sentinel lymph nodes, but not by other lymph node components such as dendritic cells, which usually express S100 protein. Commonly used melanoma markers, such as anti-HMB-45 and anti-Melan-A, are poorly expressed in desmoplastic melanomas while SOX-10 is moderately-to-strongly expressed in desmoplastic melanomas. SOX-10 is considered as a very reliable marker for recognizing residual desmoplastic melanomas. In normal tissues, it is expressed in Schwann cells, melanocytes, and myoepithelial cells of salivary, bronchial and mammary glands. SOX-10 expression is also observed in mast cells.
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    Recombinant human SOX10 protein fragment (around aa115-269) (exact sequence is proprietary)
    Klon
    SOX10-1074
    Isotyp
    IgG2b kappa
    Top Product
    Discover our top product SOX10 Primärantikörper
  • Applikationshinweise

    Positive Control: HepG2 cells. Melanomas, breast carcinomas, gliomas.

    Known Application: Western Blot (0.5-1.0 μg/mL), Immunohistochemistry (Formalin-fixed) (0.5-1 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    SOX10 (SRY (Sex Determining Region Y)-Box 10 (SOX10))
    Andere Bezeichnung
    SOX10 (SOX10 Produkte)
    Synonyme
    DOM antikoerper, PCWH antikoerper, WS2E antikoerper, WS4 antikoerper, WS4C antikoerper, SOX-10 antikoerper, SOX10 antikoerper, dom antikoerper, ws4 antikoerper, Dom antikoerper, Sox21 antikoerper, SOX9 antikoerper, cls/sox10 antikoerper, zgc:100757 antikoerper, SRY-box 10 antikoerper, SRY box 10 antikoerper, SRY-box 10 L homeolog antikoerper, SRY (sex determining region Y)-box 10 antikoerper, SOX10 antikoerper, Sox10 antikoerper, sox10.L antikoerper, sox10 antikoerper
    Molekulargewicht
    49-58kDa
    Gen-ID
    6663
    UniProt
    P56693
    Pathways
    Chromatin Binding
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