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Perforin 1 Antikörper (AA 413-552)

PRF1 Reaktivität: Human IHC, ELISA, Coat Wirt: Maus Monoclonal PRF1-2468 unconjugated
Produktnummer ABIN6940387
  • Target Alle Perforin 1 (PRF1) Antikörper anzeigen
    Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))
    Bindungsspezifität
    • 8
    • 7
    • 5
    • 5
    • 4
    • 4
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 413-552
    Reaktivität
    • 86
    • 26
    • 11
    • 7
    • 6
    • 5
    • 2
    • 1
    • 1
    • 1
    Human
    Wirt
    • 57
    • 47
    • 4
    Maus
    Klonalität
    • 58
    • 50
    Monoklonal
    Konjugat
    • 59
    • 13
    • 11
    • 5
    • 4
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Perforin 1 Antikörper ist unkonjugiert
    Applikation
    • 51
    • 40
    • 30
    • 25
    • 16
    • 10
    • 8
    • 7
    • 6
    • 5
    • 5
    • 5
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunohistochemistry (IHC), ELISA, Coating (Coat)
    Aufreinigung
    Purified by Protein A/G
    Immunogen
    Recombinant human Perforin-1 protein fragment (around aa 413-552) (exact sequence is proprietary)
    Klon
    PRF1-2468
    Isotyp
    IgG2b kappa
    Top Product
    Discover our top product PRF1 Primärantikörper
  • Applikationshinweise

    Positive Control: HDLM-2 cells. Human spleen tissue (IHC).

    Known Application: ELISA (For coating, order Ab without BSA), Optimal dilution for a specific application should be determined.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    200 μg/mL
    Buffer
    10 mM PBS with 0.05 % BSA & 0.05 % azide.
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-80 °C
    Informationen zur Lagerung
    Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.
    Haltbarkeit
    24 months
  • Target
    Perforin 1 (PRF1) (Perforin 1 (Pore Forming Protein) (PRF1))
    Andere Bezeichnung
    PRF1 (PRF1 Produkte)
    Synonyme
    FLH2 antikoerper, HPLH2 antikoerper, P1 antikoerper, PFN1 antikoerper, PFP antikoerper, PRF1 antikoerper, Pfn antikoerper, Pfp antikoerper, Prf-1 antikoerper, Cyta antikoerper, RATCYTA antikoerper, LOC443187 antikoerper, perforin antikoerper, prf1 antikoerper, cytolysin antikoerper, perforin-1 antikoerper, perforin-1-like antikoerper, perforin 1 antikoerper, perforin 1 (pore forming protein) antikoerper, perforin antikoerper, perforin 1 L homeolog antikoerper, PRF1 antikoerper, Prf1 antikoerper, LOC443187 antikoerper, prf1 antikoerper, prf1.L antikoerper
    Hintergrund
    Perforin is a pore-forming protein that leads to osmotic lysis of the target cells and subsequently enables granzymes to enter the target cells and activate apoptosis. Perforin has structural and functional similarities to complement component 9 (C9). Like C9, this protein creates transmembrane tubules and is capable of lysing non-specifically a variety of target cells. It is one of the main cytolytic proteins of cytolytic granules, and is known to be a key effector molecule for T-cell- and natural killer-cell-mediated cytolysis. Defects in this gene cause familial hemophagocytic lymphohistiocytosis type 2 (HPLH2), a rare and lethal autosomal recessive disorder of early childhood. The expression of perforin is reportedly upregulated in activated CD8+ T-cells, natural killer cells and some CD4+ T-cells.
    Molekulargewicht
    75kDa
    Gen-ID
    5551
    UniProt
    P14222
    Pathways
    Apoptose, Caspase Kaskade in der Apoptose
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