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Laminin gamma 1 Antikörper

LAMC1 Reaktivität: Maus IF, FACS, IHC (f) Wirt: Ratte Monoclonal A5 unconjugated
Produktnummer ABIN6937767
  • Target Alle Laminin gamma 1 (LAMC1) Antikörper anzeigen
    Laminin gamma 1 (LAMC1) (Laminin, gamma 1 (LAMC1))
    Reaktivität
    • 46
    • 23
    • 19
    • 5
    • 4
    • 4
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 38
    • 9
    • 4
    Ratte
    Klonalität
    • 37
    • 14
    Monoklonal
    Konjugat
    • 35
    • 5
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Laminin gamma 1 Antikörper ist unkonjugiert
    Applikation
    • 31
    • 21
    • 16
    • 13
    • 8
    • 6
    • 4
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Immunofluorescence (IF), Flow Cytometry (FACS), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Spezifität
    Laminins are large hetero-trimeric, non-collagenous glycoproteins composed of alpha, beta, and gamma chains. This MAb reacts with laminin B2/1 chain of ~210 kDa and does not cross-react with other basement membrane components or fibronectin. Its specificity was established by immunoprecipitation and immunofluorescence of human skeletal muscle and kidney with laminin chain-specific MAbs. Epithelial sheets in vivo are separated from the mesenchymal elements of the stroma by a thin layer of a specialized type of extracellular matrix termed the basement membrane (BM). This structure consists of individual components, some of which are ubiquitous in BMs and some are not. The ubiquitous ones comprise laminin (LN), entactin/nidogen (EN), collagen type IV (CIV), and large heparan sulfate proteoglycan (HSPG), which interact specifically with each other to form a continuous and regular BM. Alterations of BM integrity, from local discontinuities up to complete loss, are described in many types of human and animal epithelial neoplasms. This MAb stains uniformly all human and murine basement membranes.
    Kreuzreaktivität (Details)
    Human. Mouse.
    Aufreinigung
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Murine EHS laminin preparation
    Klon
    A5
    Isotyp
    IgG2a kappa
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  • Applikationshinweise

    Known_Application: Flow Cytometry (1-2 μg/million cells), Immunofluorescence (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Positive_Control: Normal colon or carcinomas.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Konservierungsmittel
    Azide free
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Haltbarkeit
    24 months
  • Target
    Laminin gamma 1 (LAMC1) (Laminin, gamma 1 (LAMC1))
    Andere Bezeichnung
    LAMC1 (LAMC1 Produkte)
    Synonyme
    lamb2 antikoerper, Lamb2 antikoerper, B2e antikoerper, sly antikoerper, LAMB2 antikoerper, putative laminin gamma-1 chain antikoerper, laminin subunit gamma 1 antikoerper, laminin, gamma 1 antikoerper, Smp_163810 antikoerper, lamc1 antikoerper, Lamc1 antikoerper, LAMC1 antikoerper
    Hintergrund
    LAMB2, LAMC1, Laminin B2 chain, Laminin gamma 1, Laminin gamma 1 chain,Laminin, gamma 1 (LAMC1)
    Cellular localisation: Basement membrane
    Molekulargewicht
    210kDa
    Gen-ID
    3915, 609663
    UniProt
    P11047, Q5VYE7, Q6NVY8
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