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Rekombinanter GP2 Antikörper (AA 35-179)

GP2 Reaktivität: Human ELISA, WB, Coat, IHC (f) Wirt: Kaninchen Monoclonal GP2-2569R unconjugated Recombinant Antibody
Produktnummer ABIN6937336
  • Target Alle GP2 Produkte
    GP2 (Glycoprotein 2 (Zymogen Granule Membrane) (GP2))
    Antikörpertyp
    Recombinant Antibody
    Bindungsspezifität
    • 28
    • 8
    • 7
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    AA 35-179
    Reaktivität
    • 49
    • 8
    • 4
    • 2
    • 2
    • 1
    Human
    Wirt
    • 32
    • 26
    Kaninchen
    Klonalität
    • 29
    • 29
    Monoklonal
    Konjugat
    • 30
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    Dieser GP2 Antikörper ist unkonjugiert
    Applikation
    • 34
    • 31
    • 22
    • 20
    • 20
    • 12
    • 9
    • 9
    • 4
    • 3
    • 2
    • 1
    • 1
    ELISA, Western Blotting (WB), Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
    Spezifität
    GP2 (glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.
    Keine Kreuzreaktivität
    Maus
    Kreuzreaktivität (Details)
    Human. Does not react with Mouse.
    Aufreinigung
    1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
    Immunogen
    Recombinant human GP2 protein fragment (around aa35-179) (exact sequence is proprietary)
    Klon
    GP2-2569R
    Isotyp
    IgG
  • Applikationshinweise

    Known_Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.

    Positive_Control: PANC-1 cells. Pancreas.

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Konzentration
    1.0 mg/mL
    Buffer
    Prepared in 10 mM PBS, WITHOUT BSA and Azide.
    Konservierungsmittel
    Azide free
    Lagerung
    -20 °C,-80 °C
    Informationen zur Lagerung
    Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
    Haltbarkeit
    24 months
  • Target
    GP2 (Glycoprotein 2 (Zymogen Granule Membrane) (GP2))
    Andere Bezeichnung
    GP2 (GP2 Produkte)
    Synonyme
    ZAP75 antikoerper, 2310037I18Rik antikoerper, AV060639 antikoerper, gp80 antikoerper, glycoprotein 2 antikoerper, glycoprotein 2 (zymogen granule membrane) antikoerper, GP2 antikoerper, Gp2 antikoerper
    Substanzklasse
    Viral Protein
    Hintergrund
    Glycoprotein 2 (zymogen granule membrane), GP2, Pancreatic zymogen granule membrane associated protein GP2, Pancreatic zymogen granule membrane protein GP-2, ZAP75,GP2 (Glycoprotein 2) / ZAP75
    Cellular localisation: Cell Surface and Secreted
    Molekulargewicht
    59kDa
    Gen-ID
    2813, 53985
    UniProt
    P55259
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