Rekombinanter GP2 Antikörper (AA 35-179)
-
- Target Alle GP2 Produkte
- GP2 (Glycoprotein 2 (Zymogen Granule Membrane) (GP2))
- Antikörpertyp
- Recombinant Antibody
-
Bindungsspezifität
- AA 35-179
-
Reaktivität
- Human
-
Wirt
- Kaninchen
-
Klonalität
- Monoklonal
-
Konjugat
- Dieser GP2 Antikörper ist unkonjugiert
-
Applikation
- ELISA, Western Blotting (WB), Coating (Coat), Immunohistochemistry (Formalin-fixed Sections) (IHC (f))
- Spezifität
- GP2 (glycoprotein 2), also known as ZAP75, is a 537 amino acid secreted protein. It is an integral membrane protein that is secreted from intracellular zymogen granules and associates with the plasma membrane via glycosylphosphatidylinositol (GPI) linkage. GP2 is cleaved and then released into the pancreatic duct along with exocrine secretions. GP2 binds pathogens such as enterobacteria, thereby playing an important role in the innate immune response. The C-terminus of this protein is related to the C-terminus of the protein encoded by the neighboring gene, uromodulin (UMOD). GP2 is also expressed on the apical plasma membrane of specialized microfold (M) cells among enterocytes and serves as a transcytotic receptor for mucosal antigens. M cells are considered a promising target for oral vaccination against various infectious diseases.
- Keine Kreuzreaktivität
- Maus
- Kreuzreaktivität (Details)
- Human. Does not react with Mouse.
- Aufreinigung
- 1.0mg/ml of Ab purified from Bioreactor by Protein A/G.
- Immunogen
- Recombinant human GP2 protein fragment (around aa35-179) (exact sequence is proprietary)
- Klon
- GP2-2569R
- Isotyp
- IgG
-
-
- Applikationshinweise
-
Known_Application: ELISA (Use Ab at 2-4 μg/mL for coating) (Order Ab without BSA), Western Blot (1-2 μg/mL), Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT)(Staining of formalin-fixed tissues requires heating tissue sections in 10 mM Tris with 1 mM EDTA, pH 9.0, for 45 min at 95°C followed by cooling at RT for 20 minutes), Optimal dilution for a specific application should be determined.
Positive_Control: PANC-1 cells. Pancreas.
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
-
- Konzentration
- 1.0 mg/mL
- Buffer
- Prepared in 10 mM PBS, WITHOUT BSA and Azide.
- Konservierungsmittel
- Azide free
- Lagerung
- -20 °C,-80 °C
- Informationen zur Lagerung
- Antibody without azide store at -20 to -80 °C. Antibody is stable for 24 months. Non-hazardous.
- Haltbarkeit
- 24 months
-
- Target
- GP2 (Glycoprotein 2 (Zymogen Granule Membrane) (GP2))
- Andere Bezeichnung
- GP2 (GP2 Produkte)
- Synonyme
- ZAP75 antikoerper, 2310037I18Rik antikoerper, AV060639 antikoerper, gp80 antikoerper, glycoprotein 2 antikoerper, glycoprotein 2 (zymogen granule membrane) antikoerper, GP2 antikoerper, Gp2 antikoerper
- Substanzklasse
- Viral Protein
- Hintergrund
-
Glycoprotein 2 (zymogen granule membrane), GP2, Pancreatic zymogen granule membrane associated protein GP2, Pancreatic zymogen granule membrane protein GP-2, ZAP75,GP2 (Glycoprotein 2) / ZAP75
Cellular localisation: Cell Surface and Secreted - Molekulargewicht
- 59kDa
- Gen-ID
- 2813, 53985
- UniProt
- P55259
-