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ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) (AA 1051-1280) Antikörper (Cy3)

ABCB1B Reaktivität: Human, Maus, Ratte WB, FACS, IF (cc), IF (p) Wirt: Kaninchen Polyclonal Cy3
Produktnummer ABIN686980
  • Target Alle ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B) Antikörper anzeigen
    ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B)
    Bindungsspezifität
    • 15
    • 8
    • 8
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1051-1280
    Reaktivität
    • 31
    • 23
    • 23
    • 4
    • 4
    • 4
    • 4
    Human, Maus, Ratte
    Wirt
    • 34
    • 13
    Kaninchen
    Klonalität
    • 34
    • 13
    Polyklonal
    Konjugat
    • 13
    • 6
    • 5
    • 5
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    Cy3
    Applikation
    • 22
    • 20
    • 17
    • 13
    • 13
    • 6
    • 4
    • 4
    • 4
    • 3
    • 1
    Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))
    Kreuzreaktivität
    Human, Maus, Ratte
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human MDR1
    Isotyp
    IgG
    Top Product
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  • Applikationshinweise
    FCM 1:20-100
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
    Haltbarkeit
    12 months
  • Target
    ATP-Binding Cassette, Sub-Family B (MDR/TAP), Member 1B (ABCB1B)
    Andere Bezeichnung
    MDR1 (ABCB1B Produkte)
    Synonyme
    ABC20 antikoerper, CD243 antikoerper, CLCS antikoerper, GP170 antikoerper, MDR1 antikoerper, P-GP antikoerper, PGY1 antikoerper, Abcb1 antikoerper, Mdr1 antikoerper, Mdr1b antikoerper, Pgy-1 antikoerper, Pgy1 antikoerper, mdr antikoerper, ATP binding cassette subfamily B member 1 antikoerper, ATP-binding cassette, sub-family B (MDR/TAP), member 1B antikoerper, ATP-binding cassette, subfamily B (MDR/TAP), member 1B antikoerper, ABCB1 antikoerper, Abcb1b antikoerper
    Hintergrund

    Synonyms: P-Glycoprotein, Multi Drug Resistance Associated Protein, ABCB1, ATP-binding cassette sub-family B MDR/TAP, member 1, ABC20, CD243, CD243 antigen, CLCS, Multidrug resistance protein 1, P glycoprotein 1, p-GP, gp170, P gp, PGY1.

    Background: P Glycoprotein, the product of the MDR1 gene, is expressed in distinct non-malignant cells, typically cells with secretory and excretory functions. It is assumed to function as an ATP-dependent drug efflux pump with broad substrate specificity. The highest expression of P Glycoprotein has been observed in kidney (proximal tubules), liver (bile canaliculi), adrenal gland and intestine, suggesting that the primary role of P Glycoprotein is in the normal secretion of physiological metabolites and ingested chemicals into bile, urine and the lumen of the intestinal tract. Elevated levels of P Glycoprotein have also been reported in multidrug-resistant cell lines and in colon, endometrial, ovarian, and breast tumors, as well as in sarcomas and leukemias / lymphomas.

    Gen-ID
    5243
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