TP53BP1 Antikörper (pSer25, pSer29)

Produktnummer ABIN682993

Produktdetails anti-TP53BP1 Antikörper

Target: TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))

Bindungsspezifität: pSer25, pSer29

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TP53BP1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität: This phosphorylated site is the same in Mouse and homologous to p53BP1 Ser30 + Ser34 in Rat.

Kreuzreaktivität: Human, Maus, Ratte

Homologie: Dog,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic phosphopeptide derived from human p53BP1 around the phosphorylation site of Ser25/29

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200
ICC 1:100-500

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-TP53BP1 Antikörper (ABIN682993)

Cai, Cao, Zhang, Xue, Zhang, Zhou, Zhou, Sun, Fu: "Oncogenic miR-17/20a Forms a Positive Feed-forward Loop with the p53 Kinase DAPK3 to Promote Tumorigenesis." in: The Journal of biological chemistry, Vol. 290, Issue 32, pp. 19967-75, (2015) (PubMed).

Details zu TP53BP1

Target: TP53BP1 (Tumor Protein P53 Binding Protein 1 (TP53BP1))

Andere Bezeichnung: p53BP1 + (TP53BP1 Produkte)

Synonyme: TP53BP1 antikoerper, MGC160112 antikoerper, 53BP1 antikoerper, Tp53bp1 antikoerper, m53BP1 antikoerper, p202 antikoerper, Trp53bp1 antikoerper, tumor protein p53 binding protein 1 antikoerper, tumor suppressor p53-binding protein 1 antikoerper, tumor protein p53 binding protein 1 (predicted), 5 prime antikoerper, transformation related protein 53 binding protein 1 antikoerper, TP53BP1 antikoerper, tp53bp1 antikoerper, LOC100550605 antikoerper, Trp53bp1 antikoerper, Tp53bp1 antikoerper

Hintergrund:

Synonyms: p202, 53BP1, Tumor suppressor p53-binding protein 1, p53-binding protein 1, p53BP1, TP53BP1

Background: Plays a key role in the response to DNA damage. May have a role in checkpoint signaling during mitosis. Enhances TP53-mediated transcriptional activation.

Gen-ID: 7158

UniProt: Q12888

Pathways: DNA Reparatur