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Sorting Nexin 1 Antikörper (AA 401-522)

SNX1 Reaktivität: Ratte ELISA, IF (cc), IF (p), IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN682078
  • Target Alle Sorting Nexin 1 (SNX1) Antikörper anzeigen
    Sorting Nexin 1 (SNX1)
    Bindungsspezifität
    • 14
    • 12
    • 8
    • 6
    • 4
    • 4
    • 4
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 401-522
    Reaktivität
    • 60
    • 39
    • 22
    • 4
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Ratte
    Wirt
    • 68
    • 5
    • 3
    • 1
    Kaninchen
    Klonalität
    • 65
    • 12
    Polyklonal
    Konjugat
    • 32
    • 7
    • 6
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser Sorting Nexin 1 Antikörper ist unkonjugiert
    Applikation
    • 40
    • 30
    • 13
    • 13
    • 12
    • 7
    • 6
    • 5
    • 2
    • 2
    • 1
    • 1
    ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Ratte
    Homologie
    Human,Mouse,Dog,Pig,Horse,Chicken,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human SNX1/Sorting nexin1.
    Isotyp
    IgG
    Top Product
    Discover our top product SNX1 Primärantikörper
  • Applikationshinweise
    ELISA 1:500-1000
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    Sorting Nexin 1 (SNX1)
    Andere Bezeichnung
    SNX1 (SNX1 Produkte)
    Synonyme
    d254 antikoerper, sb:cb923 antikoerper, snx1 antikoerper, wu:fb40c08 antikoerper, wu:fj65g09 antikoerper, MGC82200 antikoerper, SNX1 antikoerper, HsT17379 antikoerper, VPS5 antikoerper, ARABIDOPSIS THALIANA SORTING NEXIN 1 antikoerper, ATSNX1 antikoerper, K16F4.11 antikoerper, K16F4_11 antikoerper, sorting nexin 1 antikoerper, sorting nexin 1a antikoerper, sorting nexin 1 L homeolog antikoerper, sorting nexin 1 antikoerper, sorting nexin-1 antikoerper, snx1a antikoerper, snx1.L antikoerper, SNX1 antikoerper, snx1 antikoerper, LOC100380673 antikoerper, Snx1 antikoerper
    Hintergrund

    Synonyms: VPS5, HsT17379, Sorting nexin-1, SNX1

    Background: Involved in several stages of intracellular trafficking. Interacts with membranes containing phosphatidylinositol 3-phosphate (PtdIns(3P)) or phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (PubMed:12198132). Acts in part as component of the retromer membrane-deforming SNX-BAR subcomplex. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX-BAR subcomplex functions to deform the donor membrane into a tubular profile called endosome-to-TGN transport carrier (ETC) (Probable). Can sense membrane curvature and has in vitro vesicle-to-membrane remodeling activity (PubMed:19816406, PubMed:23085988). Involved in retrograde endosome-to-TGN transport of lysosomal enzyme receptors (IGF2R, M6PR and SORT1) and Shiginella dysenteria toxin stxB. Plays a role in targeting ligand-activated EGFR to the lysosomes for degradation after endocytosis from the cell surface and release from the Golgi (PubMed:12198132, PubMed:15498486, PubMed:17550970, PubMed:17101778, PubMed:18088323, PubMed:21040701). Involvement in retromer-independent endocytic trafficking of P2RY1 and lysosomal degradation of protease-activated receptor-1/F2R (PubMed:16407403, PubMed:20070609). Promotes KALRN- and RHOG-dependent but retromer-independent membrane remodeling such as lamellipodium formation, the function is dependent on GEF activity of KALRN (PubMed:20604901). Required for endocytosis of DRD5 upon agonist stimulation but not for basal receptor trafficking (PubMed:23152498).

    Gen-ID
    6642
    UniProt
    Q13596
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