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TAP2 Antikörper (AA 451-550)

TAP2 Reaktivität: Human, Maus WB, ELISA, IF (cc), IF (p), FACS, IHC (p), IHC (fro) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN680123
  • Target Alle TAP2 Antikörper anzeigen
    TAP2 (Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP2))
    Bindungsspezifität
    • 15
    • 15
    • 7
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 451-550
    Reaktivität
    • 34
    • 19
    • 18
    Human, Maus
    Wirt
    • 50
    Kaninchen
    Klonalität
    • 50
    Polyklonal
    Konjugat
    • 13
    • 4
    • 4
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser TAP2 Antikörper ist unkonjugiert
    Applikation
    • 39
    • 25
    • 25
    • 15
    • 14
    • 10
    • 5
    • 5
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
    Kreuzreaktivität
    Human, Maus
    Homologie
    Rat,Dog,Cow,Pig,Horse,Rabbit
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human TAP2
    Isotyp
    IgG
    Top Product
    Discover our top product TAP2 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    IHC-F 1:100-500
    IF(IHC-P) 1:50-200
    IF(IHC-F) 1:50-200
    IF(ICC) 1:50-200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Target
    TAP2 (Transporter 2, ATP-Binding Cassette, Sub-Family B (MDR/TAP) (TAP2))
    Andere Bezeichnung
    TAP2/ABCB3 (TAP2 Produkte)
    Synonyme
    ABC18 antikoerper, ABCB3 antikoerper, APT2 antikoerper, D6S217E antikoerper, PSF-2 antikoerper, PSF2 antikoerper, RING11 antikoerper, AI462429 antikoerper, Abcb3 antikoerper, Ham-2 antikoerper, Ham2 antikoerper, MTP2 antikoerper, Tap-2 antikoerper, Y1 antikoerper, jas antikoerper, Cim antikoerper, transporter 2, ATP binding cassette subfamily B member antikoerper, transporter 2, ATP-binding cassette, sub-family B (MDR/TAP) antikoerper, TAP2 antikoerper, Tap2 antikoerper
    Hintergrund

    Synonyms: Uncharacterized protein C9orf172, C9orf172

    Background: TAP is an integral transmembrane protein involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. It is a heterodimer of TAP1 and TAP2, and the peptide-binding site is shared between the cytoplasmic loops of TAP1 and TAP2. TAP is inducible by interferon gamma and belongs to the ABC transporter family, MDR subfamily. TAP also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. TAP is inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. It is inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP and prevents the conformational rearrangement of TAP induced by peptide binding.

    Gen-ID
    389813
    UniProt
    C9J069
    Pathways
    Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process
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