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NR1I2 Antikörper (AA 51-150)

NR1I2 Reaktivität: Human, Maus, Schwein WB, ELISA, FACS, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN679598
  • Target Alle NR1I2 Antikörper anzeigen
    NR1I2 (Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))
    Bindungsspezifität
    • 15
    • 15
    • 7
    • 6
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 51-150
    Reaktivität
    • 69
    • 42
    • 28
    • 17
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Human, Maus, Schwein
    Wirt
    • 75
    • 8
    • 1
    Kaninchen
    Klonalität
    • 78
    • 6
    Polyklonal
    Konjugat
    • 38
    • 10
    • 7
    • 4
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Dieser NR1I2 Antikörper ist unkonjugiert
    Applikation
    • 78
    • 27
    • 19
    • 18
    • 13
    • 13
    • 12
    • 7
    • 7
    • 4
    • 4
    • 3
    • 2
    • 1
    Western Blotting (WB), ELISA, Flow Cytometry (FACS), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Kreuzreaktivität
    Human, Maus, Schwein
    Homologie
    Rat,Cow,Horse
    Aufreinigung
    Purified by Protein A.
    Immunogen
    KLH conjugated synthetic peptide derived from human PXR
    Isotyp
    IgG
    Top Product
    Discover our top product NR1I2 Primärantikörper
  • Applikationshinweise
    WB 1:300-5000
    ELISA 1:500-1000
    FCM 1:20-100
    IHC-P 1:200-400
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 μg/μL
    Buffer
    0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.
    Konservierungsmittel
    ProClin
    Vorsichtsmaßnahmen
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
    Haltbarkeit
    12 months
  • Zhou, Li, Wang, Jin, Shi, Wang, Bi: "Cecropin B Represses CYP3A29 Expression through Activation of the TLR2/4-NF-κB/PXR Signaling Pathway." in: Scientific reports, Vol. 6, pp. 27876, (2016) (PubMed).

    Sehirli, Cetinel, Ozkan, Selman, Tetik, Yuksel, Dulger: "St. John's wort may ameliorate 2,4,6-trinitrobenzenesulfonic acid colitis off rats through the induction of pregnane X receptors and/or P-glycoproteins." in: Journal of physiology and pharmacology : an official journal of the Polish Physiological Society, Vol. 66, Issue 2, pp. 203-14, (2015) (PubMed).

  • Target
    NR1I2 (Nuclear Receptor Subfamily 1, Group I, Member 2 (NR1I2))
    Andere Bezeichnung
    PXR (NR1I2 Produkte)
    Synonyme
    BXR antikoerper, ONR1 antikoerper, PAR antikoerper, PAR1 antikoerper, PAR2 antikoerper, PARq antikoerper, PRR antikoerper, PXR antikoerper, SAR antikoerper, SXR antikoerper, PXR.1 antikoerper, PXR.2 antikoerper, PXR1 antikoerper, mPXR antikoerper, bxr antikoerper, nr1i2 antikoerper, onr1 antikoerper, xonr1 antikoerper, nuclear receptor subfamily 1 group I member 2 antikoerper, nuclear receptor subfamily 1, group I, member 2 antikoerper, nuclear receptor subfamily 1 group I member 2 S homeolog antikoerper, NR1I2 antikoerper, Nr1i2 antikoerper, nr1i2.S antikoerper, nr1i2 antikoerper
    Hintergrund

    Synonyms: BXR, PAR, PRR, PXR, SAR, SXR, ONR1, PAR1, PAR2, PARq, Nuclear receptor subfamily 1 group I member 2, Orphan nuclear receptor PAR1, Orphan nuclear receptor PXR, Pregnane X receptor, Steroid and xenobiotic receptor, NR1I2

    Background: Nuclear receptor that binds and is activated by variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, drugs and endogenous compounds. Activated by the antibiotic rifampicin and various plant metabolites, such as hyperforin, guggulipid, colupulone, and isoflavones. Response to specific ligands is species-specific. Activated by naturally occurring steroids, such as pregnenolone and progesterone. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes.

    Gen-ID
    8856
    UniProt
    O75469
    Pathways
    Nuclear Receptor Transcription Pathway, Steroid Hormone Mediated Signaling Pathway
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