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CYP11A1 Antikörper (AA 288-337)

CYP11A1 Reaktivität: Human WB, IHC, IHC (p) Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6744438
  • Target Alle CYP11A1 Antikörper anzeigen
    CYP11A1 (Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1))
    Bindungsspezifität
    • 16
    • 6
    • 5
    • 4
    • 4
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 288-337
    Reaktivität
    • 47
    • 25
    • 24
    • 17
    • 2
    • 2
    • 1
    Human
    Wirt
    • 49
    • 3
    Kaninchen
    Klonalität
    • 51
    • 1
    Polyklonal
    Konjugat
    • 33
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser CYP11A1 Antikörper ist unkonjugiert
    Applikation
    • 49
    • 15
    • 14
    • 13
    • 13
    • 9
    • 8
    • 7
    • 6
    • 5
    • 2
    • 1
    • 1
    Western Blotting (WB), Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Marke
    IHC-plus™
    Spezifität
    Human CYP11A1
    Homologie
    Percent identity by BLAST analysis: Human (100%).
    Aufreinigung
    Immunoaffinity purified
    Immunogen
    Synthetic peptide located between aa288-337 of human CYP11A1 (P05108, NP_000772). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla (100%), Monkey (92%).

    Type of Immunogen: Synthetic peptide
    Isotyp
    IgG
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    Discover our top product CYP11A1 Primärantikörper
  • Applikationshinweise
    Approved: IHC, IHC-P (5 μg/mL), WB (1 μg/mL)

    Usage: Immunohistochemistry: This antibody was validated for use in immunohistochemistry on a panel of 21 formalin-fixed, paraffin-embedded (FFPE) human tissues after heat induced antigen retrieval in  pH 6.0 citrate buffer. After incubation with the primary antibody, slides were incubated with biotinylated secondary antibody, followed by alkaline phosphatase-streptavidin and chromogen. The stained slides were evaluated by a pathologist to confirm staining specificity. The optimal working concentration for this antibody was determined to be 5 μg/mL. ELISA titer using peptide based assay: 1:1562500. Western Blot: Suggested dilution at 1 μg/mL in 5 % skim milk / PBS buffer, and HRP conjugated anti-Rabbit IgG should be diluted in 1:50000 - 100000 as second antibody.
    Kommentare

    Target Species of Antibody: Human

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Lyophilized
    Rekonstitution
    Distilled Water.
    Konzentration
    Lot specific
    Buffer
    Lyophilized from PBS with 2 % sucrose
    Handhabung
    Avoid repeat freeze-thaw cycles.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Long term: -20°C, the use of 50% glycerol is recommended if storing aliquots in -20°C for long term use (up to 1 year)
    Short term (less than 1 week): 4°C. Avoid freeze-thaw cycles.
  • Jia, Domenico, Takeda, Han, Wang, Armstrong, Reisdorph, OConnor, Lucas, Gelfand: "Steroidogenic enzyme Cyp11a1 regulates Type 2 CD8+ T cell skewing in allergic lung disease." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 110, Issue 20, pp. 8152-7, (2013) (PubMed).

  • Target
    CYP11A1 (Cytochrome P450, Family 11, Subfamily A, Polypeptide 1 (CYP11A1))
    Andere Bezeichnung
    P450SCC / CYP11A1 (CYP11A1 Produkte)
    Synonyme
    CYP11A antikoerper, CYP11A1 antikoerper, CYPXIA1 antikoerper, P450SCC antikoerper, Cyp11a antikoerper, Cypxia1 antikoerper, D9Ertd411e antikoerper, P450scc antikoerper, Scc antikoerper, cscc antikoerper, P450(scc) antikoerper, SSC antikoerper, cytochrome P450 family 11 subfamily A member 1 antikoerper, cholesterol side-chain cleavage enzyme, mitochondrial-like antikoerper, cytochrome P450 cholesterol side-chain cleavage antikoerper, cytochrome P450, family 11, subfamily a, polypeptide 1 antikoerper, cytochrome P450, family 11, subfamily A, polypeptide 1 antikoerper, CYP11A1 antikoerper, LOC101827747 antikoerper, Cyp11a1 antikoerper
    Hintergrund
    Name/Gene ID: CYP11A1
    Family: Cytochrome P450

    Synonyms: CYP11A1, Cholesterol 20-22 desmolase, Cholesterol desmolase, Cytochrome P450 11A1, Cytochrome P450C11A1, CYP11A, Cytochrome P450(scc), p450SCC, Steroid 20-22-lyase, CYPXIA1
    Gen-ID
    1583
    NCBI Accession
    NP_000772
    UniProt
    P05108
    Pathways
    Metabolism of Steroid Hormones and Vitamin D, Steroid Hormone Biosynthesis, C21-Steroid Hormone Metabolic Process, Cellular Response to Molecule of Bacterial Origin
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