Aggrecan Antikörper (AA 101-220)

Produktnummer ABIN673599

Produktdetails anti-Aggrecan Antikörper

Target: Aggrecan (ACAN)

Bindungsspezifität: AA 101-220

Reaktivität: Human, Ratte, Maus, Kaninchen

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Aggrecan Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Kreuzreaktivität: Human, Maus, Kaninchen, Ratte

Homologie: Dog,Cow,Pig,Horse,Chicken

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human Aggrecan core protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:300-5000
ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Referenzen für anti-Aggrecan Antikörper (ABIN673599)

Hu, Yang, Chen, Sun, Lin, Yang: "Optimization of puncture injury to rat caudal disc for mimicking early degeneration of intervertebral disc." in: Journal of orthopaedic research : official publication of the Orthopaedic Research Society, (2017) (PubMed).

Zhao, Hao, Wang, Wang: "Effect of Choline on the Composition and Degradation Enzyme of Extracellular Matrix of Mice Chondrocytes Exposed to Fluoride." in: Biological trace element research, (2016) (PubMed).

Liu, Yu, Ma, Xiang, Hu, Chen: "Lentivirus-mediated TGF-β3, CTGF and TIMP1 gene transduction as a gene therapy for intervertebral disc degeneration in an in vivo rabbit model." in: Experimental and therapeutic medicine, Vol. 11, Issue 4, pp. 1399-1404, (2016) (PubMed).

Shi, Ma, Zhang, Li, Jiang, Qin: "Hypoxia combined with spheroid culture improves cartilage specific function in chondrocytes." in: Integrative biology : quantitative biosciences from nano to macro, (2015) (PubMed).

Lei, Li, Li, Gao, Chen, Jin: "Mesenchymal stem cell characteristics of dental pulp and periodontal ligament stem cells after in vivo transplantation." in: Biomaterials, Vol. 35, Issue 24, pp. 6332-43, (2014) (PubMed).

Ren, Liu, Ma, Liu, Diao, Yang, Zhang, Xi, Hu: "Treatment of rabbit intervertebral disc degeneration with co-transfection by adeno-associated virus-mediated SOX9 and osteogenic protein-1 double genes in vivo." in: International journal of molecular medicine, Vol. 32, Issue 5, pp. 1063-8, (2014) (PubMed).

Details zu Aggrecan

Target: Aggrecan (ACAN)

Andere Bezeichnung: Aggrecan core protein 1 (ACAN Produkte)

Synonyme: AGC1 antikoerper, AGCAN antikoerper, CSPG1 antikoerper, CSPGCP antikoerper, MSK16 antikoerper, SEDK antikoerper, Agc antikoerper, Agc1 antikoerper, Cspg1 antikoerper, b2b183Clo antikoerper, cmd antikoerper, aggrecan antikoerper, aggrecan core protein antikoerper, ACAN antikoerper, Acan antikoerper, LOC100380783 antikoerper, AGC antikoerper

Hintergrund:

Synonyms: AGC1, SEDK, AGCAN, CSPG1, MSK16, CSPGCP, Aggrecan core protein, Cartilage-specific proteoglycan core protein, CSPCP, Chondroitin sulfate proteoglycan core protein 1, Chondroitin sulfate proteoglycan 1, ACAN

Background: This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region.

Gen-ID: 176

UniProt: P16112

Pathways: Glycosaminoglycan Metabolic Process, Dicarboxylic Acid Transport