ATF3 Antikörper (Activating Transcription Factor 3) (AA 120-170)

Details for Product anti-ATF3 Antibody No. ABIN6712594
Antigen
  • zgc:55526
  • ATF3
  • LRG-21
  • LRF-1
  • LRFI
  • atf-3
  • activating transcription factor 3
  • activating transcription factor 3 L homeolog
  • atf3
  • ATF3
  • Atf3
  • atf3.L
Epitop
AA 120-170
21
18
15
10
10
8
4
2
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
124
45
40
6
6
4
4
3
3
2
2
1
1
Wirt
Kaninchen
99
27
1
Klonalität
Polyklonal
Konjugat
Dieser ATF3 Antikörper ist unkonjugiert
4
4
3
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Applikation
Immunohistochemistry (IHC)
95
55
29
23
14
13
9
8
4
4
3
3
2
1
Optionen
Immunogen Synthetic peptide, corresponding to amino acids 120-170 of Human ATF3.
Spezifität ATF-3 (N159) polyclonal antibody detects endogenous levels of ATF-3 protein.
Reinigung The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Reinheit > 95% (by SDS-PAGE)
Plasmids, Primers & others Plasmide, Primers & weitere ATF3 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung ATF3 (ATF3 Antibody Abstract)
Hintergrund Activating transcription factor 3 is a member of the mammalian activation transcription factor/cAMP responsive element-binding (CREB) protein family of transcription factors. It encodes a protein with a calculated molecular mass of 22 kD. ATF3 represses rather than activates transcription from promoters with ATF binding elements. An alternatively spliced form of ATF3 (ATF3 delta Zip) encodes a truncated form ATF3 protein lacking the leucine zipper protein-dimerization motif and does not bind to DNA. In contrast to ATF3, ATF3 delta Zip stimulates transcription presumably by sequestering inhibitory co-factors away from the promoter. It is possible that alternative splicing of the ATF3 gene may be physiologically important in the regulation of target genes. Three transcript variants encoding two different isoforms have been found for this gene.
Molekulargewicht ~ 21 kDa
UniProt P18847
Pathways Myometrial Relaxation and Contraction, ER-Nucleus Signaling, Unfolded protein response
Applikations-hinweise IHC: 1:50~1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 1 mg/mL
Buffer 1 mg/mL in Phosphate buffered saline (PBS) with 0.05 % sodium azide, approx. pH 7.2.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid freeze-thaw cycles.
Lagerung 4 °C,-20 °C
Informationen zur Lagerung Store at 4°C short term. Aliquot and store at -20°C long term.
Produkt verwendet in: Zhao, Ding, Tie, Sun, Jiang, Zhao, Lin, Cui: "miRNA expression pattern associated with prognosis in elderly patients with advanced OPSC and OCC." in: International journal of oncology, Vol. 43, Issue 3, pp. 839-49, 2014 (PubMed).

Takahashi, Yoshizaki, Hiranaka, Suzuki, Yui, Akanuma, Kanazawa, Yoshida, Naito, Fujiya, Kohgo, Ieko: "Endoplasmic reticulum stress suppresses lipin-1 expression in 3T3-L1 adipocytes." in: Biochemical and biophysical research communications, Vol. 431, Issue 1, pp. 25-30, 2013 (PubMed).

Haben Sie etwas anderes gesucht?