IL1B Antikörper (Interleukin 1, beta)

Details for Product anti-IL1B Antibody No. ABIN6672481
Antigen
Reaktivität
Human, Maus, Ratte (Rattus)
328
166
121
35
21
15
15
13
11
9
8
5
4
4
4
2
2
1
Wirt
Kaninchen
397
161
11
9
8
6
2
2
Klonalität
Polyklonal
Konjugat
Dieser IL1B Antikörper ist unkonjugiert
83
33
24
10
6
4
4
4
3
3
3
3
3
3
3
1
1
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
412
327
161
61
55
46
41
38
27
27
24
21
20
17
14
4
4
3
3
3
3
2
2
2
1
1
1
1
1
1
Optionen
Immunogen Recombinant protein of human IL1B
Isotyp IgG
Reinigung Affinity purification
Antigen
Andere Bezeichnung IL1B (IL1B Antibody Abstract)
Hintergrund The 20S proteasome is the major proteolytic enzyme complex involved in intracellular protein degradation. PA700, PA28, and PA200 are three major protein Interleukin-1beta (IL-1beta), one of the major caspase-1 targets, is a multifunctional cytokine that is involved in a host of immune and proinflammatory responses. It is produced primarily by activated monocytes and macrophages. It signals through various adaptor proteins and kinases that lead to activation of numerous downstream targets. Human IL-1beta is synthesized as a 31 kDa precursor. To gain activity, the precursor must be cleaved by caspase-1 between Asp116 and Ala117 to yield a 17 kDa mature form. Detection of the 17 kDa mature form of IL-1beta is a good indicator of caspase-1 activity.
Synonyms: IL1B, IL-1, IL1-BETA, IL1F2 , IL1beta
Gen-ID 3553
UniProt P01584
Pathways NF-kappaB Signalweg, Interferon-gamma Pathway, Negative Regulation of Hormone Secretion, Cellular Response to Molecule of Bacterial Origin, Carbohydrate Homeostasis, Glycosaminoglycan Metabolic Process, Myometrial Relaxation and Contraction, Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Autophagie, Cancer Immune Checkpoints
Applikations-hinweise Recommended dilutions: WB: 1:500-1:2000, IHC: 1:50-1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Buffer PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid freeze / thaw cycles
Lagerung -20 °C,-80 °C
Informationen zur Lagerung

Storage: -20 °C/-80 °C

Bilder des Herstellers
Image no. 1 for anti-Interleukin 1, beta (IL1B) antibody (ABIN6672481) anti-Interleukin 1, beta (IL1B) antibody (Image 1)
Image no. 2 for anti-Interleukin 1, beta (IL1B) antibody (ABIN6672481) anti-Interleukin 1, beta (IL1B) antibody (Image 2)
Produkt verwendet in: Wu, Zhang, Qi, Zhang, Li, Li, Lin, Bai, Liu, Chen, Yang, Xu, Zhang, Yang: "Nicotine promotes atherosclerosis via ROS-NLRP3-mediated endothelial cell pyroptosis." in: Cell death & disease, Vol. 9, Issue 2, pp. 171, 2018 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB)

Qin, Yang, Huang, Du, Mai, Xiao, Lü: "Sulforaphane attenuates microglia-mediated neuronal necroptosis through down-regulation of MAPK/NF-κB signaling pathways in LPS-activated BV-2 microglia." in: Pharmacological research, Vol. 133, pp. 218-235, 2018 (PubMed). Von den Autoren verwendete Methode: ELISA (ELISA), Western Blotting (WB)

Zhou, Du, Liu, Zhao, Yuan, Li, Chen, Lu, Cheng, Liu: "Polyacetylene glycoside attenuates ischemic kidney injury by co-inhibiting inflammation, mitochondria dysfunction and lipotoxicity." in: Life sciences, Vol. 204, pp. 55-64, 2018 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB), Immunofluorescence (IF)

Du, Qiao, Chen, Chen, Liu, Lin, Wang, Xie: "Toll-Like Receptor 4 Mediates Methamphetamine-Induced Neuroinflammation through Caspase-11 Signaling Pathway in Astrocytes." in: Frontiers in molecular neuroscience, Vol. 10, pp. 409, 2017 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB)

Wang, Shi, Dou, Li, Shi, Jiang, Wang, Yu, Chen, Wang, Xiao, Hou, Feng, Shen, Ma, Han: "Negative regulation of Nod-like receptor protein 3 inflammasome activation by T cell Ig mucin-3 protects against peritonitis." in: Immunology, Vol. 153, Issue 1, pp. 71-83, 2017 (PubMed). Von den Autoren verwendete Methode: ELISA (ELISA)

Liu, Zhang, Cheng, Lu, Liu: "Sustained release of hepatocyte growth factor by cationic self-assembling peptide/heparin hybrid hydrogel improves β-cell survival and function through modulating inflammatory response." in: International journal of nanomedicine, Vol. 11, pp. 4875-4890, 2017 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB)

Yang, Zhang, Wang, Zhang, Li: "Puerarin decreases bone loss and collagen destruction in rats with ligature-induced periodontitis." in: Journal of periodontal research, Vol. 50, Issue 6, pp. 748-57, 2017 (PubMed). Von den Autoren verwendete Methode: Western Blotting (WB)