GABRA5 Antikörper (Cytoplasmic Loop)

Produktnummer ABIN6658274

Produktdetails anti-GABRA5 Antikörper

Target: GABRA5 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 5 (GABRA5))

Bindungsspezifität: Cytoplasmic Loop

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GABRA5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Aufreinigung: Anti-GABA(A) Receptor alpha 5 Antibody is directed against rat GABA(A) Receptor alpha 5. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification. Reactivity is expected from the following species based on 100% sequence homology: bovine, chicken, canine, human, mouse, non-human primate, and zebra fish.

Immunogen:

Immunogen: Anti-GABA(A) Receptor alpha 5 Antibody was produced by repeated immunizations with recombinant fusion proteins from the cytoplasmic loop of the alpha 5 subunit.

Immunogen Type: Recombinant Protein

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise:

Application Note: Anti-GABA(A) Receptor alpha 5 (Rabbit) antibody is suitable for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 55 kDa in size corresponding to the alpha 5 subunit of the GABA(A) receptor in Western Blots of rat brain extracts.

Western Blot Dilution: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. This product is stable at 4° C as an undiluted liquid. For extended storage, aliquot contents and freeze at -20° C or below. Avoid cycles of freezing and thawing. Dilute only prior to immediate use.

Details zu GABRA5

Target: GABRA5 (gamma-aminobutyric Acid (GABA) A Receptor, alpha 5 (GABRA5))

Andere Bezeichnung: GABA(A) Receptor alpha 5 (GABRA5 Produkte)

Synonyme: GABRA5 antikoerper, si:dkey-93p24.1 antikoerper, A230018I05Rik antikoerper, gamma-aminobutyric acid type A receptor alpha5 subunit antikoerper, gamma-aminobutyric acid (GABA) A receptor, alpha 5 antikoerper, gamma-aminobutyric acid type A receptor alpha 5 subunit antikoerper, gamma-aminobutyric acid (GABA) A receptor, subunit alpha 5 antikoerper, gamma-aminobutyric acid receptor subunit alpha-5 antikoerper, GABRA5 antikoerper, gabra5 antikoerper, Gabra5 antikoerper, LOC100653497 antikoerper

Hintergrund:

Synonyms: Gamma-aminobutyric acid receptor subunit alpha-5, GABA(A) receptor subunit alpha-5, Gabra5

Background: Anti-GABA(A) Receptor alpha 5 Antibody detects GABA(A) Receptor alpha 4. Gamma-aminobutyric acid (GABA) is the primary inhibitory neurotransmitter in the central nervous system, causing a hyperpolarization of the membrane through the opening of a Cl- channel associated with the GABAA receptor (GABAA-R) subtype. GABAA-Rs are important therapeutic targets for a range of sedative, anxiolytic, and hypnotic agents and are implicated in several diseases including epilepsy, anxiety, depression, and substance abuse. The GABAA-R is a multimeric subunit complex. To date six alphas, four betas and four gammas, plus alternative splicing variants of some of these subunits, have been identified. Injection in oocytes or mammalian cell lines of cRNA coding for alpha- and beta-subunits results in the expression of functional GABAA-Rs sensitive to GABA. However, coexpression of a gamma-subunit is required for benzodiazepine modulation. The various effects of the benzodiazepines in brain may also be mediated via different alpha-subunits of the receptor. GABA(A) receptor alpha 5 antibody is ideal for investigators involved in Neuroscience.

Gene Name: GABRA5

Gen-ID: 29707

NCBI Accession: NP_058991

UniProt: P19969

Pathways: Sensory Perception of Sound, Synaptic Membrane