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PAK1/2/3 Antikörper (pThr402)

PAK1/2/3 Reaktivität: Ratte WB Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6658268
  • Target Alle PAK1/2/3 Antikörper anzeigen
    PAK1/2/3 (P21-Activated Kinases 1/2/3 (PAK1/2/3))
    Bindungsspezifität
    • 13
    • 12
    • 11
    • 11
    • 6
    • 4
    • 3
    • 3
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    pThr402
    Reaktivität
    • 35
    • 26
    • 26
    • 1
    • 1
    • 1
    Ratte
    Wirt
    • 35
    Kaninchen
    Klonalität
    • 33
    • 2
    Polyklonal
    Konjugat
    • 28
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser PAK1/2/3 Antikörper ist unkonjugiert
    Applikation
    • 21
    • 19
    • 19
    • 6
    • 4
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    Western Blotting (WB)
    Kreuzreaktivität (Details)
    Cross reactivity with PAK from other species has not been determined.
    Aufreinigung
    Anti-PAK 1/2/3 pT402 antibody is directed against rat PAK protein. The antibody was affinity purified from monospecific antiserum by immunoaffinity purification and is specific for the phosphorylated protein. The immunolabeling of PAK is completely eliminated by lambda-phosphatase treatment. Reactivity is expected from the following species based on 100% sequence homology: bovine, canine, human and mouse.
    Immunogen

    Immunogen: Anti-PAK 1/2/3 pT402 Antibody was produced by repeated immunizations with a synthetic phospho-peptide corresponding to amino acid residues surrounding Thr402.

    Immunogen Type: Peptide

    Isotyp
    IgG
    Top Product
    Discover our top product PAK1/2/3 Primärantikörper
  • Applikationshinweise

    Application Note: Anti-PAK 1/2/3 pT402 Antibody is suitable for use in Western Blotting. Specific conditions for reactivity should be optimized by the end user. Expect a band of approximately 68-70 kDa in size corresponding to PAK proteins phosphorylated at Thr402 in the appropriate cell lysate or extract.

    Western Blot Dilution: 1:1000

    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Buffer

    Buffer: 0.01 M HEPES, 0.15 M Sodium Chloride, pH 7.5

    Stabilizer: 0.1 mg/mL Bovine Serum Albumin (BSA) - IgG and Protease free, 50 % (v/v) Glycerol

    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store vial at -20° C prior to opening.  This product is stable at 4° C as an undiluted liquid.  For extended storage, aliquot contents and freeze at -20° C or below.  Avoid cycles of freezing and thawing. Dilute only prior to immediate use.
  • Target
    PAK1/2/3 (P21-Activated Kinases 1/2/3 (PAK1/2/3))
    Andere Bezeichnung
    PAK 1/2/3 (PAK1/2/3 Produkte)
    Synonyme
    X-PAK1 antikoerper, XPak1 antikoerper, pak antikoerper, pak-1 antikoerper, pakalpha antikoerper, p21 protein (Cdc42/Rac)-activated kinase 1 S homeolog antikoerper, p21 (RAC1) activated kinase 1 antikoerper, pak1.S antikoerper, PAK1 antikoerper
    Hintergrund

    Synonyms: Serine/threonine-protein kinase PAK 1, Alpha-PAK, Protein kinase MUK2, p21-activated kinase 1, p68-PAK

    Background: PAK 1/2/3 pT402 Antibody detects PAK 1/2/3 pT402 proteins. In mammals, there are several identified isoforms of p21-activated protein kinases or PAKs: α-PAK (also known as PAK-1) and β-PAK (also known as PAK-3) are mostly brain-specific, while -PAK (also known as PAK-2) is expressed ubiquitously. Mutations of the gene coding for PAK-3 are associated with X-linked mental retardation and recent work indicates that PAK-3 is a key regulator of synapse formation and plasticity in the hippocampus. PAK-3 is thought to play a key role in regulation of cell shape and motility as well as cell death. Autophosphorylation of Thr402 in the protein has been found to be essential for activation of PAK. Anti-PAK 1/2/3 pT402 Antibody is ideal for investigators involved in Neuroscience and Apoptosis research.

    Gene Name: PAK1-3

    Gen-ID
    29431
    UniProt
    P35465
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