CASK Antikörper

Produktnummer ABIN6658140

Produktdetails anti-CASK Antikörper

Target: CASK (Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK))

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser CASK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Kreuzreaktivität: Human, Maus, Ratte (Rattus), Xenopus laevis, Zebrafisch (Danio rerio)

Aufreinigung: Anti-CASK Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with CASK from Mouse, Rat, Human, Zebrafish, and Xenopus based on 100% homology with the immunizing sequence. Cross-reactivity with CASK from other sources has not been determined. Scaffolds research.

Immunogen:

Immunogen: CASK Antibody was produced in mice by repeated immunizations with a fusion protein of rat CASK/Lin2.

Immunogen Type: Recombinant Protein

Klon: S56A-50

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

Immunohistochemistry Dilution: User Optimized

Application Note: Anti-CASK Antibody is suitable for use in WB, IP, and IHC. Expect a band approximately ~100 kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Immunoprecipitation Dilution: User Optimized

Western Blot Dilution: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Lagerung: RT,4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Details zu CASK

Target: CASK (Calcium/calmodulin-Dependent serine Protein Kinase (MAGUK Family) (CASK))

Andere Bezeichnung: CASK (CASK Produkte)

Synonyme: CAKI antikoerper, CAMGUK antikoerper, CG13412 antikoerper, CG13413 antikoerper, CG6703 antikoerper, CMG antikoerper, CMG/CASK antikoerper, Caki antikoerper, CamGUK antikoerper, CamguK antikoerper, Camguk antikoerper, Cask antikoerper, Cmg antikoerper, DLin-2 antikoerper, Dmel\\CG6703 antikoerper, RE09582p antikoerper, caki antikoerper, camguk antikoerper, cmg antikoerper, dCASK antikoerper, wu:fb70g06 antikoerper, CAGH39 antikoerper, FGS4 antikoerper, LIN2 antikoerper, MICPCH antikoerper, MRXSNA antikoerper, TNRC8 antikoerper, DXPri1 antikoerper, DXRib1 antikoerper, LIN-2 antikoerper, Pals3 antikoerper, mLin-2 antikoerper, CG6703 gene product from transcript CG6703-RF antikoerper, Peripheral plasma membrane protein CASK antikoerper, CAMK/CASK protein kinase antikoerper, peripheral plasma membrane protein CASK antikoerper, calcium/calmodulin-dependent serine protein kinase b antikoerper, calcium/calmodulin-dependent serine protein kinase a antikoerper, calcium/calmodulin dependent serine protein kinase antikoerper, calcium/calmodulin-dependent serine protein kinase (MAGUK family) antikoerper, calcium/calmodulin-dependent serine protein kinase (MAGUK family) S homeolog antikoerper, CASK antikoerper, Bm1_33725 antikoerper, LOAG_17286 antikoerper, Tsp_03763 antikoerper, caskb antikoerper, caska antikoerper, Cask antikoerper, cask.S antikoerper

Hintergrund:

Synonyms: Peripheral plasma membrane protein CASK, Calcium/calmodulin-dependent serine protein kinase

Background: CASK (calmodulin sensitive kinase) is a ~112 kDa member of the membrane associated quanylate kinase (MAGUK) protein family. It is an adaptor protein with a calcium/calmodulin-dependent protein kinase domain, a SH3 domain, aguanylate kinase homology domain (GUK) and a PDZ domain. CASK links transmembrane proteins to the cytoskeleton and signaling molecules. In particular, CASK binds to Neurexin to stabilize pre- and post-synaptic structrures. While most of CASK proteins are cytoplasmic, a portion of the protein enters the nucleus, where it acts as a transcriptional co-activator. Manifesting the importance of CASK, transgenic mice with insertional mutations die within 24 hours of births. CASK is also localized in the nuclei of basal keratinocytes in newborn rodent skin and developing hair follicles. It may play a role in wound healing.

Gene Name: Cask

Gen-ID: 29647

NCBI Accession: NP_071520

UniProt: Q62915

Pathways: Synaptic Vesicle Exocytosis