SCN2A Antikörper (C-Term)

Produktnummer ABIN6658123

Produktdetails anti-SCN2A Antikörper

Target: SCN2A (Sodium Channel, Voltage-Gated, Type II, alpha Subunit (SCN2A))

Bindungsspezifität: C-Term

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SCN2A Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), Immunoprecipitation (IP), Fluorescence Microscopy (FM)

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Aufreinigung: Anti-Nav1.2 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Nav1.2 from Mouse, Human, and Rat based on 100% homology with the immunizing sequence. Cross-reactivity with Nav1.2 from other sources has not been determined. Ion Channels research.

Immunogen:

Immunogen: Nav1.2 Antibody was produced in mice by repeated immunizations raised against a fusion protein corresponding to the cytoplasmic C-terminus region of rat Nav1.2.

Immunogen Type: Recombinant Protein

Klon: S69-3

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise:

Immunohistochemistry Dilution: 0.1-1.0 μg/mL

Application Note: Anti-Nav1.2 Antibody is suitable for use in WB, IP, and IHC. Expect a band approximately ~250 kDa on specific lysates. Specific conditions for reactivity should be optimized by the end user.

Immunoprecipitation Dilution: User Optimized

Western Blot Dilution: 1 μg/mL

IF Microscopy Dilution: 1.0-10 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

0.09 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: RT,4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Details zu SCN2A

Target: SCN2A (Sodium Channel, Voltage-Gated, Type II, alpha Subunit (SCN2A))

Andere Bezeichnung: Nav1.2 (SCN2A Produkte)

Synonyme: SCN2A2 antikoerper, 6430408L10 antikoerper, A230052E19Rik antikoerper, Nav1.2 antikoerper, Scn2a antikoerper, NachII antikoerper, RII/RIIA antikoerper, RNSCPIIR antikoerper, SCN antikoerper, SCN2A antikoerper, Scn2a2 antikoerper, ScpII antikoerper, BFIC3 antikoerper, BFIS3 antikoerper, BFNIS antikoerper, EIEE11 antikoerper, HBA antikoerper, HBSCI antikoerper, HBSCII antikoerper, NAC2 antikoerper, Na(v)1.2 antikoerper, SCN2A1 antikoerper, sodium voltage-gated channel alpha subunit 2 antikoerper, sodium channel protein type 2 subunit alpha antikoerper, sodium channel, voltage-gated, type II, alpha antikoerper, sodium channel, voltage-gated, type II, alpha subunit antikoerper, SCN2A antikoerper, LOC100217927 antikoerper, LOC100389294 antikoerper, LOC100484218 antikoerper, Scn2a antikoerper, LOC478773 antikoerper

Hintergrund:

Synonyms: SCN, SCN2A, ScpII, NachII, Nav1.2, Scn2a2, RII/RIIA, RNSCPIIR, Scn2a1, Sodium channel protein type 2 subunit alpha, Sodium channel protein brain II subunit alpha, Sodium channel protein type II subunit alpha, Voltage-gated Sodium channel subunit alpha Nav1.2

Background: Nav1.2 is a protein that in humans is encoded by the SCN2A gene. Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with 24 transmembrane domains and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. Neuronal Nav1.2 channels are therapeutic targets in seizure, pain and stroke.

Gene Name: Scn2a

Gen-ID: 24766

NCBI Accession: NP_036779

UniProt: P04775