SCN1A Antikörper (C-Term)

Produktnummer ABIN6658122

Produktdetails anti-SCN1A Antikörper

Target: SCN1A (Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A))

Bindungsspezifität: C-Term

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser SCN1A Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), Western Blotting (WB), Immunoprecipitation (IP), Fluorescence Microscopy (FM)

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Aufreinigung: Anti-Nav1.1 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with Nav1.1 from Mouse, Human, and Rat based on 100% homology with the immunizing sequence. No cross reactivity against Nav1.2, Nav1.3 and Nav1.6. Cross-reactivity with Nav1.1 from other sources has not been determined. Ion Channels research.

Immunogen:

Immunogen: Nav1.1 Antibody was produced in mice by repeated immunizations raised against a fusion protein corresponding to the cytoplasmic C-terminus region of rat Nav1.1.

Immunogen Type: Recombinant Protein

Klon: S74-71

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

Immunohistochemistry Dilution: 0.1-1.0 μg/mL

Application Note: Anti-Nav1.1 Antibody is suitable for use in WB, IP, and IHC. Expect a band approximately ~220 kDa on specific lysates. Epitope mapped within amino acids 690-715. Specific conditions for reactivity should be optimized by the end user.

Immunoprecipitation Dilution: User Optimized

Western Blot Dilution: 1 μg/mL

IF Microscopy Dilution: 1.0-10 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

Lagerung: RT,4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Details zu SCN1A

Target: SCN1A (Sodium Channel, Voltage-Gated, Type I, alpha Subunit (SCN1A))

Andere Bezeichnung: Nav1.1 (SCN1A Produkte)

Synonyme: SCN9A antikoerper, SCN1A antikoerper, B230332M13 antikoerper, Nav1.1 antikoerper, EIEE6 antikoerper, FEB3 antikoerper, FEB3A antikoerper, FHM3 antikoerper, GEFSP2 antikoerper, HBSCI antikoerper, NAC1 antikoerper, SCN1 antikoerper, SMEI antikoerper, sodium voltage-gated channel alpha subunit 1 antikoerper, sodium voltage-gated channel alpha subunit 9 antikoerper, sodium channel, voltage-gated, type I, alpha antikoerper, SCN1A antikoerper, SCN9A antikoerper, Scn1a antikoerper

Hintergrund:

Synonyms: FEB3, Scn1a, GEFSP2, HBSCI, SCN1, Sodium channel 3

Background: Voltage gated sodium channels initiate action potentials in neurons. Nav1.1 is abundant in the adult brain, and primarily localized in cell bodies. Mutations in the Nav1.1 channels cause generalized epilepsy with febrile seizures plus (GEFS+). Studies show that Nav1.1 channels also play a crucial role in the excitability of cerebellar Purkinje neurons, with major contributions to peak, persistent and resurgent forms of sodium current and to sustained action potential firing.

Gene Name: Scn1a

Gen-ID: 20265

NCBI Accession: NP_061203

UniProt: Q62206