DLG3 Antikörper (N-Term)

Produktnummer ABIN6658117

Produktdetails anti-DLG3 Antikörper

Target: DLG3 (Discs, Large Homolog 3 (DLG3))

Bindungsspezifität: N-Term

Reaktivität: Ratte

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser DLG3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Kreuzreaktivität: Human, Maus, Ratte (Rattus)

Aufreinigung: Anti-SAP102 Antibody was purified by Protein G chromatography. A BLAST analysis was used to suggest cross-reactivity with SAP102 from Human, Mouse, and Rat based on 100% homology with the immunizing sequence. No cross-reactivity against PSD95, SAP97 or Chapsyn-110. Cross-reactivity with SAP102 from other sources has not been determined. Organelle Markers, Neurobiology research.

Immunogen:

Immunogen: SAP102 Antibody was produced in mice by repeated immunizations raised against a fusion protein corresponding to an n-terminal region of rat SAP102.

Immunogen Type: Recombinant Protein

Klon: S19-2

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise:

Immunohistochemistry Dilution: User Optimized

Application Note: Anti-SAP102 Antibody is suitable for WB, IP, and IHC. Expect a band approximately 105 kDa protein, corresponding to the molecular mass of SAP102 on SDS Page immunoblots. Specific conditions for reactivity should be optimized by the end user.

Immunoprecipitation Dilution: User Optimized

Western Blot Dilution: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer:

Buffer: 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2

Stabilizer: 50 % (v/v) Glycerol

0.09 % (w/v) Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: RT,4 °C,-20 °C

Informationen zur Lagerung: Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.

Details zu DLG3

Target: DLG3 (Discs, Large Homolog 3 (DLG3))

Andere Bezeichnung: SAP102 (DLG3 Produkte)

Synonyme: MRX antikoerper, MRX90 antikoerper, NEDLG antikoerper, SAP102 antikoerper, XLMR antikoerper, DLG3 antikoerper, fa66c08 antikoerper, fa66e02 antikoerper, fd02c12 antikoerper, fu95c12 antikoerper, im:7138640 antikoerper, si:ch211-276g21.1 antikoerper, wu:fa66c08 antikoerper, wu:fa66e02 antikoerper, wu:fd02c12 antikoerper, wu:fu95c12 antikoerper, Dlgh3 antikoerper, mKIAA1232 antikoerper, MPP3 antikoerper, 6430514B01 antikoerper, CSG18 antikoerper, Dlg3 antikoerper, Dusp3 antikoerper, discs large MAGUK scaffold protein 3 antikoerper, membrane palmitoylated protein 3 antikoerper, discs, large homolog 3 (Drosophila) antikoerper, membrane protein, palmitoylated 3 (MAGUK p55 subfamily member 3) antikoerper, DLG3 antikoerper, MPP3 antikoerper, dlg3 antikoerper, Dlg3 antikoerper, Mpp3 antikoerper

Hintergrund:

Synonyms: DLG3, MRX90, NEDLG, XLMR, Disks large homolog 3, PSD-95/SAP90-related protein 1, Synapse-associated protein 102, SAP-102

Background: Synapse-associated protein 102 belongs to the membrane-associated guanylate kinase protein family and is a homolog of the Drosophila dis large tumor suppressor protein. SAP102 has extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminal. SAP102 consists of three 90 amino acids PDZ domains at its amino terminus, a Src homolgy 3 domain and a guanylate kinase domain. All three PDZ domains of SAP102 participate in binding to the NMDA reception, interacting specifically with the carboxy-terminal domain of the N-methyl-D-aspartate receptor 2B (NR2B). The interaction may facilitate AMPA receptor withdrawal from the postsynaptic membrane by inhibiting the ERK/MAPK pathway. SAP102 also interacts with synaptic ras-GTPase activating protein synGAP through its PDZ domains. In general, the SAP102 protein is more highly expressed in non-proliferating cells than in proliferating cells, indicating a role in the negative regulation of cell growth.

Gene Name: Dlg3

Gen-ID: 58948

NCBI Accession: NP_113827

UniProt: Q62936