LY86 Antikörper (Internal Region)
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- Target Alle LY86 Antikörper anzeigen
- LY86 (Lymphocyte Antigen 86 (LY86))
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Bindungsspezifität
- Internal Region
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Reaktivität
- Human
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Wirt
- Kaninchen
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Klonalität
- Polyklonal
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Konjugat
- Dieser LY86 Antikörper ist unkonjugiert
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Applikation
- ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
- Kreuzreaktivität
- Human, Maus, Ratte (Rattus)
- Kreuzreaktivität (Details)
- Cross reactivity with MD-1 from other sources has not been determined.
- Aufreinigung
- Anti-MD-1 Antibody was affinity purified from monospecific antiserum by immunoaffinity chromatography.
- Immunogen
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Immunogen: Anti-MD-1 antibody was prepared from whole rabbit serum produced by repeated immunizations with a 15 amino acid synthetic peptide from near the internal region of human MD-1.
Immunogen Type: Peptide
- Isotyp
- IgG
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- Applikationshinweise
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Immunohistochemistry Dilution: 2.5 μg/mL
Application Note: Anti-MD-1 Antibody has been tested for use in ELISA, Western Blotting, and Immunohistochemistry. Specific conditions for reactivity should be optimized by the end user. Expect a band at approximately 18 kDa in Western Blots of specific cell lysates and tissues.
ELISA Dilution: 1:10,000-1:20,000
Western Blot Dilution: 1-2 μg/mL
- Beschränkungen
- Nur für Forschungszwecke einsetzbar
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- Format
- Liquid
- Buffer
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Buffer: 0.01 M Sodium Phosphate, 0.25 M Sodium Chloride, pH 7.2
Stabilizer: None
- Vorsichtsmaßnahmen
- This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
- Lagerung
- RT,4 °C,-20 °C
- Informationen zur Lagerung
- Store vial at -20° C prior to opening. Aliquot contents and freeze at -20° C or below for extended storage. Avoid cycles of freezing and thawing. Centrifuge product if not completely clear after standing at room temperature. This product is stable for several weeks at 4° C as an undiluted liquid. Dilute only prior to immediate use.
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- Target
- LY86 (Lymphocyte Antigen 86 (LY86))
- Andere Bezeichnung
- MD-1 (LY86 Produkte)
- Synonyme
- MD-1 antikoerper, MMD-1 antikoerper, dJ80N2.1 antikoerper, MD1 antikoerper, LY86 antikoerper, lymphocyte antigen 86 antikoerper, LY86 antikoerper, Ly86 antikoerper
- Hintergrund
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Synonyms: MD-1 Antibody, MD-1, MMD-1, dJ80N2.1, MD1, Lymphocyte antigen 86, Protein MD-1, Ly-86
Background: Toll-like receptors (TLRs) are evolutionarily conserved pattern-recognition molecules that recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The signaling of these TLRs is kept under tight control by the expression of endogenous inhibiting proteins such as RP105, a recently identified homolog of TLR4. This protein, in association with MD-1, interacts with and inhibits the TLR4/MD-2 signaling pathway. While MD-2 can directly bind to LPS, one of the activating molecules of TLR4, the function of MD-1 is less well-known. It has been suggested however, that the RP105/MD-1 complex influences antibody production mediated by both TLR4/MD-2 and TLR2 receptor complexes.
Gene Name: LY86
- Gen-ID
- 9450
- NCBI Accession
- NP_004262
- UniProt
- O95711
- Pathways
- Toll-Like Receptors Cascades