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ALK Antikörper

ALK Reaktivität: Human IHC (p) Wirt: Kaninchen Monoclonal ATKR-2R unconjugated
Produktnummer ABIN6654206
  • Target Alle ALK Antikörper anzeigen
    ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))
    Reaktivität
    • 17
    • 3
    • 1
    • 1
    • 1
    • 1
    • 1
    Human
    Wirt
    • 17
    • 2
    Kaninchen
    Klonalität
    • 16
    • 3
    Monoklonal
    Konjugat
    • 16
    • 1
    • 1
    • 1
    Dieser ALK Antikörper ist unkonjugiert
    Applikation
    • 9
    • 8
    • 6
    • 6
    • 2
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
    Aufreinigung
    Purified
    Reinheit
    Protein A affinity
    Immunogen
    Recombinant full length human protein was used as the immunogen for this recombinant ALK antibody.
    Klon
    ATKR-2R
    Isotyp
    IgG kappa
    Top Product
    Discover our top product ALK Primärantikörper
  • Applikationshinweise
    Optimal dilution of the recombinant ALK antibody should be determined by the researcher.
    1. The prediluted format is supplied in a dropper bottle and is optimized for use in IHC. After epitope retrieval step (if required), drip mAb solution onto the tissue section and incubate at RT for 30 min.\. IHC (FFPE): 1-2 μg/mL for 30 min at RT,Prediluted IHC only format: incubate for 30 min at RT (1)
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Buffer
    0.2 mg/mL in 1X PBS with 0.1 mg/mL BSA (US sourced) and 0.05 % sodium azide
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    4 °C,-20 °C
    Informationen zur Lagerung
    Store the recombinant ALK antibody at 2-8°C (with azide) or aliquot and store at -20°C or colder (without azide).
  • Target
    ALK (Anaplastic Lymphoma Receptor tyrosine Kinase (ALK))
    Andere Bezeichnung
    ALK / Anaplastic Lymphoma Kinase (ALK Produkte)
    Synonyme
    Tcrz antikoerper, CD246 antikoerper, NBLST3 antikoerper, ALK antikoerper, anaplastic lymphoma kinase antikoerper, anaplastic lymphoma receptor tyrosine kinase antikoerper, ALK receptor tyrosine kinase antikoerper, Alk antikoerper, ALK antikoerper
    Hintergrund
    Neuronal receptor tyrosine kinase that is essentially and transiently expressed in specific regions of the central and peripheral nervous systems and plays an important role in the genesis and differentiation of the nervous system. Transduces signals from ligands at the cell surface, through specific activation of the mitogen-activated protein kinase (MAPK) pathway. Phosphorylates almost exclusively at the first tyrosine of the Y-x-x-x-Y-Y motif. Following activation by ligand, ALK induces tyrosine phosphorylation of CBL, FRS2, IRS1 and SHC1, as well as of the MAP kinases MAPK1/ERK2 and MAPK3/ERK1. Acts as a receptor for ligands pleiotrophin (PTN), a secreted growth factor, and midkine (MDK), a PTN-related factor, thus participating in PTN and MDK signal transduction. PTN-binding induces MAPK pathway activation, which is important for the anti-apoptotic signaling of PTN and regulation of cell proliferation. MDK-binding induces phosphorylation of the ALK target insulin receptor substrate (IRS1), activates mitogen-activated protein kinases (MAPKs) and PI3-kinase, resulting also in cell proliferation induction. Drives NF-kappa-B activation, probably through IRS1 and the activation of the AKT serine/threonine kinase. Recruitment of IRS1 to activated ALK and the activation of NF-kappa-B are essential for the autocrine growth and survival signaling of MDK. [UniProt]
    Pathways
    RTK Signalweg
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