IGFBP2 Antikörper (AA 35-304)

Produktnummer ABIN6654166

Produktdetails anti-IGFBP2 Antikörper

Target: IGFBP2 (Insulin-Like Growth Factor Binding Protein 2, 36kDa (IGFBP2))

Bindungsspezifität: AA 35-304

Reaktivität: Ratte, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser IGFBP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Antigen affinity purified

Immunogen: Rat IGFBP2 recombinant protein (amino acids E35-Q304) was used as the immunogen for the IGFBP2 antibody.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the IGFBP2 antibody should be determined by the researcher.\. Western blot: 0.5-1 μg/mL,Immunohistochemistry (FFPE): 1-2 μg/mL,Direct ELISA: 0.1-0.5 μg/mL (recombinant rat protein)

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: 0.5 mg/mL if reconstituted with 0.2 mL sterile DI water

Lagerung: -20 °C

Informationen zur Lagerung: After reconstitution, the IGFBP2 antibody can be stored for up to one month at 4°C. For long-term, aliquot and store at -20°C. Avoid repeated freezing and thawing.

Details zu IGFBP2

Target: IGFBP2 (Insulin-Like Growth Factor Binding Protein 2, 36kDa (IGFBP2))

Andere Bezeichnung: IGFBP2 (IGFBP2 Produkte)

Synonyme: IBP2 antikoerper, IGF-BP53 antikoerper, AI255832 antikoerper, IBP-2 antikoerper, Igfbp-2 antikoerper, mIGFBP-2 antikoerper, IGFBP-2 antikoerper, ILGFBPA antikoerper, pIGFBP-2 antikoerper, igfbp2 antikoerper, MGC65741 antikoerper, MGC76823 antikoerper, MGC174445 antikoerper, IGFBP2 antikoerper, ibp2 antikoerper, igf-bp53 antikoerper, igfbp2a antikoerper, si:ch211-2k18.3 antikoerper, insulin like growth factor binding protein 2 antikoerper, insulin-like growth factor binding protein 2 antikoerper, insulin-like growth factor binding protein 2a antikoerper, insulin-like growth factor binding protein 2b antikoerper, IGFBP2 antikoerper, Igfbp2 antikoerper, igfbp2a antikoerper, igfbp2 antikoerper, igfbp2b antikoerper

Hintergrund: The superfamily of insulin-like growth factor (IGF) binding proteins include the six high-affinity IGF binding proteins (IGFBP) and at least four additional low-affinity binding proteins referred to as IGFBP related proteins (IGFBP-rP). All IGFBP superfamily members are cysteine-rich proteins with conserved cysteine residues, which are clustered in the amino- and carboxy-terminal thirds of the molecule. IGFBPs modulate the biological activities of IGF proteins. Some IGFBPs may also have intrinsic bioactivity that is independent of their ability to bind IGF proteins. Post-translational modifications of IGFBPs, including glycosylation, phosphorylation and proteolysis, have been shown to modify the affinities of the binding proteins to IGF. Human IGFBP-2 cDNA encodes a 328 amino acid (aa) residue precursor protein with a putative 39 aa residue signal peptide that is processed to generate the 289 aa residue mature protein. IGFBP-2 contains an integrin receptor recognition sequence (RGD sequence) but lacks potential N-linked glycosylation sites. During development, IGFBP-2 is expressed in a number of tissues. The highest expression level is found in the central nervous system. In adults, high expression levels are also detected in the central nervous system and in a number of reproductive tissues. IGFBP-2 binds preferentially to IGF II, exhibiting a 2-10 fold higher affinity for IGF II than for IGF I.

UniProt: P12843

Pathways: Myometrial Relaxation and Contraction, Growth Factor Binding, Activated T Cell Proliferation