MAPT Antikörper (pSer396)

Produktnummer ABIN196790

Produktdetails anti-MAPT Antikörper

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Bindungsspezifität: pSer396

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MAPT Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: Immunoaffinity chromatography.

Immunogen: The antiserum was produced against synthesized phosphopeptide derived from Human Tau around the phosphorylation site of Serine 396 (Y-K-Sp-P-V).

Anwendungsinformationen

Applikationshinweise: Western blot: 1/500approx. 1/1000. Immunohistochemistry: 1/50approx. 1/100.
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: PBS (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % Sodium Azide and 50 % Glycerol.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: Store the antibody (in aliquots) at -20 °C.

Referenzen für anti-MAPT Antikörper (ABIN196790)

Thysiadis, Mpousis, Avramidis, Katsamakas, Balomenos, Remelli, Efthimiopoulos, Sarli: "Discovery of novel phenoxazinone derivatives as DKK1/LRP6 interaction inhibitors: Synthesis, biological evaluation and structure-activity relationships." in: Bioorganic & medicinal chemistry, Vol. 24, Issue 5, pp. 1014-22, (2016) (PubMed).

Mpousis, Thysiadis, Avramidis, Katsamakas, Efthimiopoulos, Sarli: "Synthesis and evaluation of gallocyanine dyes as potential agents for the treatment of Alzheimer's disease and related neurodegenerative tauopathies." in: European journal of medicinal chemistry, Vol. 108, pp. 28-38, (2016) (PubMed).

Eritja, Santacana, Maiques, Gonzalez-Tallada, Dolcet, Matias-Guiu: "Modeling glands with PTEN deficient cells and microscopic methods for assessing PTEN loss: endometrial cancer as a model." in: Methods (San Diego, Calif.), Vol. 77-78, pp. 31-40, (2015) (PubMed).

Jiang, Wang, Wang, Hawke, Zheng, Li, Zhou, Majumder, Bi, Liu, Huang, Lu: "PKM2 phosphorylates MLC2 and regulates cytokinesis of tumour cells." in: Nature communications, Vol. 5, pp. 5566, (2015) (PubMed).

Bockmeyer, Kern, Forstmeier, Lovric, Modde, Agustian, Steffens, Birschmann, Traeder, Dämmrich, Schwarz, Kreipe, Bröcker, Becker: "Arteriolar vascular smooth muscle cell differentiation in benign nephrosclerosis." in: Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association, Vol. 27, Issue 9, pp. 3493-501, (2013) (PubMed).

Gui, Han, Zhang, Liang, Wang, Xuan, Yu, Shang: "Dimerization of ZIP promotes its transcriptional repressive function and biological activity." in: The international journal of biochemistry & cell biology, Vol. 44, Issue 6, pp. 886-95, (2012) (PubMed).

Lu, Berglund, Larsson, Höög, Farnebo, Bränström: "Calmodulin and calmodulin-dependent protein kinase II inhibit hormone secretion in human parathyroid adenoma." in: The Journal of endocrinology, Vol. 208, Issue 1, pp. 31-9, (2011) (PubMed).

Ishiguro, Ando, Maeda, Watanabe, Goto: "Cutting edge: tubulin ? functions as an adaptor in NFAT-importin ? interaction." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 186, Issue 5, pp. 2710-3, (2011) (PubMed).

Godfrey, Anderson, Papanastasiou, Takeuchi, Boshoff: "Inhibiting primary effusion lymphoma by lentiviral vectors encoding short hairpin RNA." in: Blood, Vol. 105, Issue 6, pp. 2510-8, (2005) (PubMed).

Dempsey, Sailor, Bowen, Türeyen, Vemuganti: "Stroke-induced progenitor cell proliferation in adult spontaneously hypertensive rat brain: effect of exogenous IGF-1 and GDNF." in: Journal of neurochemistry, Vol. 87, Issue 3, pp. 586-97, (2003) (PubMed).

Watanabe, Sugaya, Atkins, Aquilino, Yang, Borris, Brady, Blauvelt: "Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen prolongs the life span of primary human umbilical vein endothelial cells." in: Journal of virology, Vol. 77, Issue 11, pp. 6188-96, (2003) (PubMed).

Details zu MAPT

Target: MAPT (Microtubule-Associated Protein tau (MAPT))

Andere Bezeichnung: MAPT / tau (MAPT Produkte)

Synonyme: DDPAC antikoerper, FTDP-17 antikoerper, MAPTL antikoerper, MSTD antikoerper, MTBT1 antikoerper, MTBT2 antikoerper, PPND antikoerper, TAU antikoerper, AI413597 antikoerper, AW045860 antikoerper, Mtapt antikoerper, Tau antikoerper, RNPTAU antikoerper, pTau antikoerper, tau antikoerper, xtp antikoerper, MAPT antikoerper, PHF-tau antikoerper, slc6a6 antikoerper, taut antikoerper, wu:fc26e12 antikoerper, microtubule associated protein tau antikoerper, microtubule-associated protein tau antikoerper, microtubule associated protein tau S homeolog antikoerper, Microtubule-associated protein tau antikoerper, solute carrier family 6 (neurotransmitter transporter), member 6b antikoerper, MAPT antikoerper, Mapt antikoerper, mapt.S antikoerper, LOC5580230 antikoerper, CpipJ_CPIJ013260 antikoerper, tau antikoerper, slc6a6b antikoerper

Hintergrund: Tau is a neuronal microtubule associated protein found predominantly on axons. The function of Tau is to promote tubulin polymerisation and stabilise microtubules, but it also serves to link certain signalling pathways to the cytoskeleton. Tau, in its hyperphosphorylated form, is the major component of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer's disease (AD) brain. Hyperphosphorylation impairs the microtubule binding function of Tau, resulting in the destabilisation of microtubules in AD brains, ultimately leading to the degeneration of the affected neurons. Hyperphosphorylated tau is also found in a range of other central nervous system disorders. Numerous serine/threonine kinases, including GSK3 beta, PKA, Cdk5, and casein kinase II can phosphorylate Tau.Synonyms: MAPTL, MTBT1, Microtubule-associated protein tau, Neurofibrillary tangle protein, PHF-tau, Paired helical filament-tau

Gen-ID: 9606

UniProt: P10636

Pathways: MAPK Signalweg, Microtubule Dynamics, M Phase, Regulation of Cell Size