KIR2DS1 Antikörper (AA 151-180)

Produktnummer ABIN657823

Produktdetails anti-KIR2DS1 Antikörper

Target: KIR2DS1 (Killer Cell Immunoglobulin Like Receptor 2DS1 (KIR2DS1))

Bindungsspezifität: AA 151-180

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KIR2DS1 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This KIR2DS1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 151-180 amino acids from the Central region of human KIR2DS1.

Klon: RB34046

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: WB: 1:1000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: KIR2DS1 Antibody (Center) can be refrigerated at 2-8 °C for up to 6 months. For long term storage, place the at -20 °C.

Haltbarkeit: 6 months

Details zu KIR2DS1

Target: KIR2DS1 (Killer Cell Immunoglobulin Like Receptor 2DS1 (KIR2DS1))

Andere Bezeichnung: KIR2DS1 (KIR2DS1 Produkte)

Synonyme: CD158H antikoerper, CD158a antikoerper, p50.1 antikoerper, killer cell immunoglobulin like receptor, two Ig domains and short cytoplasmic tail 1 antikoerper, KIR2DS1 antikoerper

Hintergrund: Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules, thus, KIR proteins are thought to play an important role in regulation of the immune response.

Molekulargewicht: 33618

Gen-ID: 3806

NCBI Accession: NP_055327

UniProt: Q14954