Synonyms: liver,Glucose Transporter 2,Glucose Transporter GLUT2,Glucose transporter type 2,Glucose transporter type 2 liver,Glucose transporter,liver/islet,GLUT-2,GLUT2,GTR2,GTT2,SLC2A2,Solute carrier family 2 (facilitated glucose transporter) member 2,Solute carrier family 2 facilitated glucose transporter member 2,Solute carrier family 2,facilitated glucose transporter member 2
Background: This gene encodes an integral plasma membrane glycoprotein of the liver, islet beta cells, intestine, and kidney epithelium. The encoded protein mediates facilitated bidirectional glucose transport. Because of its low affinity for glucose, it has been suggested as a glucose sensor. Mutations in this gene are associated with susceptibility to diseases, including Fanconi-Bickel syndrome and noninsulin-dependent diabetes mellitus (NIDDM). Alternative splicing results in multiple transcript variants of this gene.