Laminin beta 1 Antikörper (Laminin, beta 1)

Details for Product anti-LAMB1 Antibody No. ABIN6572031
Antigen
  • CLM
  • LIS5
  • fc20b05
  • gup
  • lamb1
  • sb:cb95
  • wu:fc20b05
  • Lamb1-1
  • LAMB1
  • C77966
  • C80098
  • C81607
  • D130003D08Rik
  • Lamb-1
  • laminin subunit beta 1
  • laminin, beta 1a
  • laminin B1
  • LAMB1
  • lamb1a
  • Lamb1
  • lamb1
Reaktivität
Human, Maus
104
57
16
5
4
2
2
2
2
1
1
Wirt
Kaninchen
79
26
4
Klonalität
Polyklonal
Konjugat
Dieser Laminin beta 1 Antikörper ist unkonjugiert
6
3
3
2
2
2
2
2
2
2
2
2
1
1
Applikation
Western Blotting (WB)
93
56
50
26
25
12
10
6
6
3
2
1
Optionen
Immunogen Recombinant protein of human LAMB1
Isotyp IgG
Reinigung Affinity purification
Plasmids, Primers & others Plasmide, Primers & weitere Laminin beta 1 products on genomics-online (e.g. as negative or positive controls)
Antigen
Andere Bezeichnung Laminin beta1 (LAMB1 Antibody Abstract)
Hintergrund

Synonyms: CLM,Cutis laxa with marfanoid phenotype,LAM B1,LAMB 1,LAMB1,LAMB1,Laminin B1,Laminin B1 chain,Laminin beta 1 chain,Laminin beta 1 chain precursor,Laminin beta1,Laminin subunit beta 1,Laminin subunit beta-1,Laminin-1 subunit beta,Laminin-10 subunit beta,Laminin-12 subunit beta,Laminin-2 subunit beta,Laminin-6 subunit beta,Laminin-8 subunit beta,LIS5,MGC142015

Background: Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins are composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively) and they form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 1. The beta 1 chain has 7 structurally distinct domains which it shares with other beta chain isomers. The C-terminal helical region containing domains I and II are separated by domain alpha, domains III and V contain several EGF-like repeats, and domains IV and VI have a globular conformation. Laminin, beta 1 is expressed in most tissues that produce basement membranes, and is one of the 3 chains constituting laminin 1, the first laminin isolated from Engelbreth-Holm-Swarm (EHS) tumor. A sequence in the beta 1 chain that is involved in cell attachment, chemotaxis, and binding to the laminin receptor was identified and shown to have the capacity to inhibit metastasis.

Molekulargewicht

Observed_MW: 198kDa

Calculated_MW: 198kDa

Gen-ID 3912
UniProt P07942
Applikations-hinweise WB 1:1000 - 1:4000
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder des Herstellers
Image no. 1 for anti-Laminin, beta 1 (LAMB1) antibody (ABIN6572031) Western blot analysis of extracts of various cell lines, using LAMB1 antibody.
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