Deoxyribonuclease I (DNASE1) Antikörper

Details zu Produkt Nr. ABIN6569259
Target
Reaktivität
Human, Maus
53
22
20
17
Wirt
Kaninchen
55
12
1
Klonalität
Polyklonal
Konjugat
Unkonjugiert
11
6
3
2
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Western Blotting (WB)
50
28
19
13
11
9
7
7
4
3
2
2
1
1
1
1
Optionen
Immunogen Recombinant protein of human DNASE1
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung DNASE1 (DNASE1 Antibody Abstract)
Hintergrund

Synonyms: Deoxyribonuclease 1,Deoxyribonuclease I,Deoxyribonuclease-1,Deoxyribonuclease1,DeoxyribonucleaseI,DNAS1,DNASE 1,DNase I,DNase I lysosomal,DNASE1,DNaseI,DNL 1,DNL1,Dornase alfa,DRNI,FLJ38093,Human urine deoxyribonuclease I

Background: This gene encodes a member of the DNase family. This protein is stored in the zymogen granules of the nuclear envelope and functions by cleaving DNA in an endonucleolytic manner. At least six autosomal codominant alleles have been characterized, DNASE1*1 through DNASE1*6, and the sequence of DNASE1*2 represented in this record. Mutations in this gene have been associated with systemic lupus erythematosus (SLE), an autoimmune disease. A recombinant form of this protein is used to treat the one of the symptoms of cystic fibrosis by hydrolyzing the extracellular DNA in sputum and reducing its viscosity. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized.

Molekulargewicht

Observed_MW: 37kDa

Calculated_MW: 19kDa/31kDa

Gen-ID 1773
UniProt P24855
Applikations-hinweise WB 1:500 - 1:2000 IF 1:50 - 1:100
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Deoxyribonuclease I (DNASE1) antibody (ABIN6569259) Western blot analysis of extracts of various cell lines, using DNASE1 antibody.
Image no. 2 for anti-Deoxyribonuclease I (DNASE1) antibody (ABIN6569259) Immunofluorescence analysis of HeLa cells using DNASE1 antibody.