OAS1 Antikörper (2',5'-Oligoadenylate Synthetase 1, 40/46kDa)

Details for Product anti-OAS1 Antibody No. ABIN6569255
Target
Reaktivität
Human, Maus
63
24
12
4
4
4
3
3
1
1
1
Wirt
Kaninchen
53
7
2
1
Klonalität
Polyklonal
Konjugat
Dieser OAS1 Antikörper ist unkonjugiert
6
4
4
3
3
3
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Western Blotting (WB)
50
33
31
8
3
2
1
1
1
1
Optionen
Immunogen Recombinant protein of human OAS1
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung OAS1 (OAS1 Antibody Abstract)
Hintergrund

Synonyms: (2 5')oligo(A) synthetase 1,(2-5'')oligo(A) synthase 1,2 5 Oligoadenylate Synthetase 1,2 5' oligo A synthase 1,2 5' oligo A synthetase 1,2 5A synthase 1,2 5A synthetase 1,2' 5' oligo A synthetase 1,2' 5' oligoadenylate synthetase 1 40/46  kDa,2' 5' oligoadenylate synthetase 1,2' 5' oligoisoadenylate synthetase 1,2''-5''-oligoadenylate synthase 1,2'5' oligo A synthetase 1,2'5' oligoadenylate synthetase 1,2'5' oligoisoadenylate synthetase 1,2-5A synthase 1,E18/E16,IFI 4,IFI4 ,OAS 1,OAS1,OAS1,OIAS,OIASI,p46/p42 OAS

Background: This gene is induced by interferons and encodes a protein that synthesizes 2',5'-oligoadenylates (2-5As). This protein activates latent RNase L, which results in viral RNA degradation and the inhibition of viral replication. Alternative splicing results in multiple transcript variants with different enzymatic activities. Polymorphisms in this gene have been associated with susceptibility to viral infection and diabetes mellitus, type 1. A disease-associated allele in a splice acceptor site influences the production of the p46 splice isoform. This gene is located in a cluster of related genes on chromosome 12.

Molekulargewicht

Observed_MW: 40kDa

Calculated_MW: 41kDa/43kDa/46kDa/47kDa

Gen-ID 4938
UniProt P00973
Pathways Hepatitis C
Applikations-hinweise WB 1:500 - 1:2000 IF 1:50 - 1:100
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) antibody (ABIN6569255) Western blot analysis of extracts of mouse liver, using OAS1 antibody.
Image no. 2 for anti-2',5'-Oligoadenylate Synthetase 1, 40/46kDa (OAS1) antibody (ABIN6569255) Immunofluorescence analysis of HeLa cells using OAS1 antibody.