Synonyms: AIP1,ALG 2 interacting protein 1,ALG-2-interacting protein 1,ALG2 interacting protein X,Alix,Apoptosis linked gene 2 interacting protein X,Dopamine receptor interacting protein 4,DRIP4,Hp95,KIAA1375,MGC17003,PDC6I,PDCD6 interacting protein,PDCD6-interacting protein,PDCD6IP,Programmed cell death 6 interacting protein,Programmed cell death 6-interacting protein
Background: This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.