PDCD6IP Antikörper (Programmed Cell Death 6 Interacting Protein)

Details for Product anti-PDCD6IP Antibody No. ABIN6569187
Target
Reaktivität
Human, Maus, Ratte
79
33
31
3
1
1
1
1
1
1
Wirt
Kaninchen
56
18
7
Klonalität
Polyklonal
Konjugat
Dieser PDCD6IP Antikörper ist unkonjugiert
6
4
4
3
3
3
3
2
2
2
2
2
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
53
36
15
13
11
11
9
4
3
3
3
2
Optionen
Immunogen Recombinant protein of human PDCD6IP
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung PDCD6IP (PDCD6IP Antibody Abstract)
Hintergrund

Synonyms: AIP1,ALG 2 interacting protein 1,ALG-2-interacting protein 1,ALG2 interacting protein X,Alix,Apoptosis linked gene 2 interacting protein X,Dopamine receptor interacting protein 4,DRIP4,Hp95,KIAA1375,MGC17003,PDC6I,PDCD6 interacting protein,PDCD6-interacting protein,PDCD6IP,Programmed cell death 6 interacting protein,Programmed cell death 6-interacting protein

Background: This gene encodes a protein that functions within the ESCRT pathway in the abscission stage of cytokinesis, in intralumenal endosomal vesicle formation, and in enveloped virus budding. Studies using mouse cells have shown that overexpression of this protein can block apoptosis. In addition, the product of this gene binds to the product of the PDCD6 gene, a protein required for apoptosis, in a calcium-dependent manner. This gene product also binds to endophilins, proteins that regulate membrane shape during endocytosis. Overexpression of this gene product and endophilins results in cytoplasmic vacuolization, which may be partly responsible for the protection against cell death. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. Related pseudogenes have been identified on chromosome 15.

Molekulargewicht

Observed_MW: 109kDa

Calculated_MW: 30kDa/96kDa

Gen-ID 10015
UniProt Q8WUM4
Pathways p53 Signalweg, EGFR Signaling Pathway, Sensory Perception of Sound, Cellular Response to Molecule of Bacterial Origin, Tube Formation
Applikations-hinweise WB 1:200 - 1:2000 IHC 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Programmed Cell Death 6 Interacting Protein (PDCD6IP) antibody (ABIN6569187) Immunohistochemistry of paraffin-embedded rat kidney using PDCD6IP antibody.
Image no. 2 for anti-Programmed Cell Death 6 Interacting Protein (PDCD6IP) antibody (ABIN6569187) Western blot analysis of extracts of various cell lines, using PDCD6IP antibody.
Image no. 3 for anti-Programmed Cell Death 6 Interacting Protein (PDCD6IP) antibody (ABIN6569187) Immunohistochemistry of paraffin-embedded human stomach using PDCD6IP antibody.