Synonyms: 42 kDa,Anti GC4,cap43,cmt4d,Differentiation related gene1 protein,Differentiation-related gene 1 protein,Drg 1,DRG-1,drg1,gc4,GC4,hmsnl,Human mRNA for RTP complete cds,N myc downstream regulated gene 1,N myc downstream regulated gene 1 protein,N-myc downstream-regulated gene 1 protein,Ndr 1,ndr1,NDRG 1,Ndrg1,NDRG1 protein,NDRG1,Nickel specific induction protein,Nickel specific induction protein Cap43,Nickel-specific induction protein Cap43,nmsl,Nmyc downstream regulated,Nmyc downstream regulated gene1,Nmyc downstream regulated gene1 protein,Protein NDRG1,Protein regulated by oxygen 1,Protein regulated by oxygen1,Proxy1,Reduced in tumor,Reducin,Reducing agents and tunicamycin responsive protein,Reducing agents and tunicamycin-responsive protein,Rit42,RTP,targ1,TDD5,tdds,Tunicamycin responsive protein
Background: This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein involved in stress responses, hormone responses, cell growth, and differentiation. The encoded protein is necessary for p53-mediated caspase activation and apoptosis. Mutations in this gene are a cause of Charcot-Marie-Tooth disease type 4D, and expression of this gene may be a prognostic indicator for several types of cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.