TNFSF10 Antikörper (Tumor Necrosis Factor (Ligand) Superfamily, Member 10)

Details for Product anti-TNFSF10 Antibody No. ABIN6569130
Target
Reaktivität
Human, Maus, Ratte
144
43
26
5
3
1
1
Wirt
Kaninchen
113
54
7
2
1
Klonalität
Polyklonal
Konjugat
Dieser TNFSF10 Antikörper ist unkonjugiert
21
13
9
8
6
3
2
2
2
2
2
2
1
1
1
1
1
Applikation
Immunohistochemistry (IHC), Western Blotting (WB)
112
65
34
34
17
13
13
12
10
8
8
7
6
6
3
2
2
1
1
1
Optionen
Immunogen Recombinant protein of human TNFSF10
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung TRAIL (TNFSF10 Antibody Abstract)
Hintergrund

Synonyms: Apo 2 ligand,APO 2L,Apo-2 ligand,Apo-2L,APO2L,CD253,CD253 antigen,Chemokine tumor necrosis factor ligand superfamily member 10,Protein TRAIL,TL2,TNF Related Apoptosis Inducing Ligand,TNF related apoptosis inducing ligand TRAIL,TNF-related apoptosis-inducing ligand,TNF10,TNFSF10,TRAIL,Tumor necrosis factor (ligand) family member 10,Tumor Necrosis Factor (ligand) Superfamily Member 10,Tumor necrosis factor apoptosis inducing ligand splice variant delta,Tumor necrosis factor ligand superfamily member 10

Background: The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This protein preferentially induces apoptosis in transformed and tumor cells, but does not appear to kill normal cells although it is expressed at a significant level in most normal tissues. This protein binds to several members of TNF receptor superfamily including TNFRSF10A/TRAILR1, TNFRSF10B/TRAILR2, TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and possibly also to TNFRSF11B/OPG. The activity of this protein may be modulated by binding to the decoy receptors TNFRSF10C/TRAILR3, TNFRSF10D/TRAILR4, and TNFRSF11B/OPG that cannot induce apoptosis. The binding of this protein to its receptors has been shown to trigger the activation of MAPK8/JNK, caspase 8, and caspase 3. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

Molekulargewicht

Observed_MW: 27kDa

Calculated_MW: 11kDa/32kDa

Gen-ID 8743
UniProt P50591
Pathways Apoptose, Positive Regulation of Endopeptidase Activity
Applikations-hinweise WB 1:500 - 1:2000 IHC 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) antibody (ABIN6569130) Western blot analysis of extracts of mouse kidney, using TNFSF10 antibody.
Image no. 2 for anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) antibody (ABIN6569130) Western blot analysis of extracts of various cell lines, using TNFSF10 antibody.
Image no. 3 for anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) antibody (ABIN6569130) Immunohistochemistry of paraffin-embedded human colon carcinoma using TNFSF10 antibody.
Image no. 4 for anti-Tumor Necrosis Factor (Ligand) Superfamily, Member 10 (TNFSF10) antibody (ABIN6569130) Immunohistochemistry of paraffin-embedded mouse kidney using TNFSF10 antibody.