Synonyms: FLJ18565,Hepatocarcinoma intestine pancreas,Hepatointestinal pancreatic protein,HIP,HIP/PAP,Human proislet peptide,INGAP,Pancreatic beta cell growth factor,Pancreatitis associated protein 1,Pancreatitis associated protein,Pancreatitis-associated protein 1,PAP,PAP H,PAP homologous protein,PAP1,PBCGF,Proliferation inducing protein 34,Proliferation inducing protein 42,Reg III alpha,REG III,Reg III-alpha,REG-3-alpha,REG3,Reg3a,REG3A,Regenerating islet derived 3 alpha,Regenerating islet derived protein 3 alpha precursor,Regenerating islet-derived protein 3-alpha 15 kDa form,Regenerating islet-derived protein III-alpha
Background: This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.