Synonyms: DIRA,F630041P17Rik,ICIL 1RA,ICIL-1RA,ICIL1RA,IL-1ra,IL-1ra3,IL-1RN,IL1 inhibitor,IL1F3,IL1RA,IL1RA,IL1RN (IL1F3),IL1RN,Interleukin 1 receptor antagonist,Interleukin-1 receptor antagonist protein,Intracellular IL 1 receptor antagonist type II,Intracellular interleukin 1 receptor antagonist (icIL 1ra),IRAP,MGC10430,MVCD4,Type II interleukin 1 receptor antagonist
Background: The protein encoded by this gene is a member of the interleukin 1 cytokine family. This protein inhibits the activities of interleukin 1, alpha (IL1A) and interleukin 1, beta (IL1B), and modulates a variety of interleukin 1 related immune and inflammatory responses. This gene and five other closely related cytokine genes form a gene cluster spanning approximately 400 kb on chromosome 2. A polymorphism of this gene is reported to be associated with increased risk of osteoporotic fractures and gastric cancer. Several alternatively spliced transcript variants encoding distinct isoforms have been reported.