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IKZF1 Antikörper

IKZF1 Reaktivität: Human, Maus, Ratte IF Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN6568940
  • Target Alle IKZF1 Antikörper anzeigen
    IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))
    Reaktivität
    • 59
    • 43
    • 17
    • 5
    • 5
    • 4
    • 4
    • 4
    • 4
    • 1
    • 1
    • 1
    • 1
    Human, Maus, Ratte
    Wirt
    • 61
    • 15
    • 2
    Kaninchen
    Klonalität
    • 62
    • 16
    Polyklonal
    Konjugat
    • 39
    • 5
    • 5
    • 5
    • 4
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    Dieser IKZF1 Antikörper ist unkonjugiert
    Applikation
    • 61
    • 25
    • 23
    • 19
    • 13
    • 13
    • 10
    • 8
    • 7
    • 4
    • 3
    • 3
    • 2
    • 1
    • 1
    • 1
    • 1
    Immunofluorescence (IF)
    Aufreinigung
    Affinity purification
    Immunogen
    Recombinant fusion protein of human IKZF1 (NP_001207694.1).
    Isotyp
    IgG
    Top Product
    Discover our top product IKZF1 Primärantikörper
  • Applikationshinweise
    IF 1:50-1:200
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    1 mg/mL
    Buffer
    PBS with 0.02 % sodium azide, 50 % glycerol, pH 7.3
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
    Informationen zur Lagerung
    Store at -20°C. Avoid freeze / thaw cycles.
  • Target
    IKZF1 (IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1))
    Andere Bezeichnung
    IKZF1 (IKZF1 Produkte)
    Synonyme
    Hs.54452 antikoerper, IK1 antikoerper, IKAROS antikoerper, LYF1 antikoerper, PRO0758 antikoerper, ZNFN1A1 antikoerper, hIk-1 antikoerper, RGD1562979 antikoerper, ikaros antikoerper, znfn1a1 antikoerper, ik1 antikoerper, lyf1 antikoerper, hik-1 antikoerper, pro0758 antikoerper, hs.54452 antikoerper, MGC108252 antikoerper, 5832432G11Rik antikoerper, Ikaros antikoerper, LyF-1 antikoerper, Zfpn1a1 antikoerper, Znfn1a1 antikoerper, hlk-1 antikoerper, mKIAA4227 antikoerper, ikzf1 antikoerper, IKAROS family zinc finger 1 antikoerper, IKAROS family zinc finger 1 (Ikaros) antikoerper, IKZF1 antikoerper, Ikzf1 antikoerper, ikzf1 antikoerper
    Hintergrund
    This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).
    Molekulargewicht

    Observed_MW: 46kDa

    Calculated_MW: 24-31kDa/41-57kDa

    Gen-ID
    10320
    UniProt
    Q13422
    Pathways
    Production of Molecular Mediator of Immune Response
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