IKZF1 Antikörper (IKAROS Family Zinc Finger 1 (Ikaros))

Details for Product anti-IKZF1 Antibody No. ABIN6568940
Target
Reaktivität
Human, Maus, Ratte
75
35
27
6
5
4
4
4
4
1
1
1
1
Wirt
Kaninchen
57
12
8
Klonalität
Polyklonal
Konjugat
Dieser IKZF1 Antikörper ist unkonjugiert
6
5
5
5
3
3
2
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Western Blotting (WB)
62
31
26
23
13
8
7
4
3
2
2
2
1
1
Optionen
Immunogen Recombinant protein of human IKZF1
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung IKZF1 (IKZF1 Antibody Abstract)
Hintergrund

Synonyms: CLL associated antigen KW 6,DNA-binding protein Ikaros,hIk 1,Hs.54452,IK1,Ikaros (zinc finger protein),IKAROS,IKAROS family zinc finger 1 (Ikaros),Ikaros family zinc finger protein 1,Ikzf1,IKZF1,LYF1,Lymphoid transcription factor LyF-1,PRO0758,Zinc finger protein subfamily 1A 1 (Ikaros),Zinc finger protein subfamily 1A 1,Zinc finger protein, subfamily 1A, member 1,ZNFN1A1

Background: This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL).

Molekulargewicht

Observed_MW: 46kDa

Calculated_MW: 24-31kDa/41-57kDa

Gen-ID 10320
UniProt Q13422
Pathways Production of Molecular Mediator of Immune Response
Applikations-hinweise WB 1:500 - 1:2000 IF 1:50 - 1:200
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) antibody (ABIN6568940) Western blot analysis of extracts of BT-474 cells, using IKZF1 antibody.
Image no. 2 for anti-IKAROS Family Zinc Finger 1 (Ikaros) (IKZF1) antibody (ABIN6568940) Immunofluorescence analysis of U2OS cells using IKZF1 antibody.