Synonyms: CaCC,CaCC-1,CACC1,Calcium dependent chloride channel 1,Calcium-activated chloride channel family member 1,Calcium-activated chloride channel protein 1,Calcium-activated chloride channel regulator 1,Chloride channel calcium activated family member 1,Chloride channel regulator 1,CLCA family member 1 chloride channel regulator,CLCA1,CLCA1,CLCRG1,GOB5,hCaCC-1,hCLCA1
Background: This gene encodes a member of the calcium sensitive chloride conductance protein family. To date, all members of this gene family map to the same region on chromosome 1p31-p22 and share a high degree of homology in size, sequence, and predicted structure, but differ significantly in their tissue distributions. The encoded protein is expressed as a precursor protein that is processed into two cell-surface-associated subunits, although the site at which the precursor is cleaved has not been precisely determined. The encoded protein may be involved in mediating calcium-activated chloride conductance in the intestine.