Factor VIII Antikörper (Coagulation Factor VIII)

Details for Product anti-F8 Antibody No. ABIN6568110
Target
Reaktivität
Maus, Ratte
132
50
31
20
10
3
2
2
2
1
1
1
Wirt
Kaninchen
105
38
11
3
1
Klonalität
Polyklonal
Konjugat
Dieser Factor VIII Antikörper ist unkonjugiert
18
17
9
3
3
3
3
3
3
3
3
3
3
3
2
2
2
Applikation
Western Blotting (WB)
83
60
39
34
18
13
12
11
9
6
5
5
3
2
2
2
2
1
1
1
1
1
Optionen
Immunogen Recombinant protein of human F8
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung Factor VIII (F8 Antibody Abstract)
Hintergrund

Synonyms: AHF,Antihemophilic factor,Coagulation factor VIII,coagulation factor VIII,procoagulant component,coagulation factor VIIIc,DXS1253E,F8,F8b,F8c,FA8,factor VIII F8B,Factor VIIIa light chain,FactorVIII,FVIII,Hema,Hemophilia A,Hemophilia,classic,OTTHUMP00000061446,OTTHUMP00000196174,Procoagulant component

Background: This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation, factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

Molekulargewicht

Observed_MW: 240kDa

Calculated_MW: 24kDa/267kDa

Gen-ID 2157
UniProt P00451
Applikations-hinweise WB 1:500 - 1:2000
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Coagulation Factor VIII (F8) antibody (ABIN6568110) Western blot analysis of extracts of various cell lines, using F8 antibody.