Synonyms: DKFZp434B0920,DKFZp686G0837,E3 ubiquitin-protein ligase UHRF2,MGC33463,Np95 like RING finger protein,Np95-like ring finger protein,Np95/ICBP90 like RING finger protein,Np95/ICBP90-like RING finger protein,Nuclear protein 97,Nuclear zinc finger protein Np97,RING finger protein 107,RNF 107,RP11-472F14.2,Ubiquitin like containing PHD and RING finger domains protein 2,Ubiquitin-like PHD and RING finger domain-containing protein 2,Ubiquitin-like-containing PHD and RING finger domains protein 2,Uhrf2,UHRF2,URF 2
Background: This gene encodes a nuclear protein which is involved in cell-cycle regulation. The encoded protein is a ubiquitin-ligase capable of ubiquinating PCNP (PEST-containing nuclear protein), and together they may play a role in tumorigenesis. The encoded protein contains an NIRF_N domain, a PHD finger, a set- and ring-associated (SRA) domain, and a RING finger domain and several of these domains have been shown to be essential for the regulation of cell proliferation. This protein may also have a role in intranuclear degradation of polyglutamine aggregates. Alternative splicing results in multiple transcript variants some of which are non-protein coding.