Fibrillarin Antikörper (FBL)

Details for Product anti-FBL Antibody No. ABIN6568000
Target
Reaktivität
Human, Affe, Maus, Ratte
53
34
30
6
4
3
2
2
2
2
2
1
1
1
1
1
1
Wirt
Kaninchen
37
16
9
Klonalität
Polyklonal
Konjugat
Dieser Fibrillarin Antikörper ist unkonjugiert
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
48
16
15
14
13
8
6
4
2
1
1
1
1
1
1
1
Optionen
Immunogen Recombinant protein of human FBL
Isotyp IgG
Reinigung Affinity purification
Target
Andere Bezeichnung FBL (FBL Antibody Abstract)
Hintergrund

Synonyms: 34 kD nucleolar scleroderma antigen,34 kDa nucleolar scleroderma antigen,Fbl,FBRL,FIB,FIB1,FLRN,Histone-glutamine methyltransferase,Nop1p,RNA U3 small nucleolar interacting protein 1,RNU3IP1,rRNA 2' O methyltransferase fibrillarin,rRNA 2'-O-methyltransferase fibrillarin

Background: This gene product is a component of a nucleolar small nuclear ribonucleoprotein (snRNP) particle thought to participate in the first step in processing preribosomal RNA. It is associated with the U3, U8, and U13 small nuclear RNAs and is located in the dense fibrillar component (DFC) of the nucleolus. The encoded protein contains an N-terminal repetitive domain that is rich in glycine and arginine residues, like fibrillarins in other species. Its central region resembles an RNA-binding domain and contains an RNP consensus sequence. Antisera from approximately 8 % of humans with the autoimmune disease scleroderma recognize fibrillarin.

Molekulargewicht

Observed_MW: 37kDa

Calculated_MW: 33kDa

Gen-ID 2091
UniProt P22087
Pathways Ribonucleoside Biosynthetic Process
Applikations-hinweise WB 1:500 - 1:2000 IHC 1:50 - 1:200 IF 1:50 - 1:200 IP 1:20 - 1:50
Beschränkungen Nur für Forschungszwecke einsetzbar
Konzentration 1 mg/mL
Buffer Buffer: PBS with 0.02 % sodium azide, 50 % glycerol,  pH 7.3.
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C. Avoid freeze / thaw cycles.
Bilder
Image no. 1 for anti-Fibrillarin (FBL) antibody (ABIN6568000) Immunohistochemistry of paraffin-embedded mouse liver using FBL antibody.
Image no. 2 for anti-Fibrillarin (FBL) antibody (ABIN6568000) Immunoprecipitation analysis of 200ug extracts of HeLa cells using 1ug FBL antibody.
Image no. 3 for anti-Fibrillarin (FBL) antibody (ABIN6568000) Immunofluorescence analysis of A549 cells using FBL antibody.
Image no. 4 for anti-Fibrillarin (FBL) antibody (ABIN6568000) Western blot analysis of extracts of various cell lines, using FBL antibody.